000			06797nam a22004335i 4500
001			86229
003			ES-MaUEC
005			20230207040548.0
007			cr nn 008mamaa
008			160915s2016 gw | s |||| 0|eng d
020			_a9783319412832
040			_aES-MaUEC
050		4	_aQP535.S5 _bS454 2016
082	0	4	_a616.079
245	1	0	_aSelenium : _bIts Molecular Biology and Role in Human Health _cedited by Dolph L Hatfield, Ulrich Schweizer, Petra A Tsuji, Vadim N Gladyshev
250			_a4th ed.
260			_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XXXI, 628 p.) _b88 ilustraciones, 59 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPart I. The machinery of selenoprotein biosynthesis -- 1 Selenocysteine tRNA[Ser]Sec: From nonsense suppressor tRNA to the quintessential constituent in selenoprotein biosynthesis -- 2 Eukaryotic mechanisms of selenocysteine translation and its reconstitution in vitro -- 3 Probing selenoprotein translation by ribosome profiling -- 4 Pathways in de novo biosynthesis of selenocysteine and cysteine in eukaryotes -- 5 Prokaryotic selenoprotein biosynthesis and function -- 6 The role of selenium in human evolution -- 7 The chemistry of selenocysteine in proteins -- 8 Evolution of selenophosphate synthetase -- 9 Structure and mechanism of selenocysteine synthases -- 10 Mechanism, structure, and biological role of selenocysteine lyase -- Part II. Selenoproteins, their occurrence and function -- 11 Eukaryotic selenoproteomes -- 12 Prokaryotic selenoproteins and selenoproteomes -- 13 Functional genomics of selenoproteins and Se-responsive pathways -- 14 Selenium regulation of the selenoprotein and non-selenoprotein transcriptomes in a variety of species -- 15 77Se NMR spectroscopy of selenoproteins -- 16 Thioredoxin reductase 1 as an anticancer drug target -- 17 Basics and news on glutathione peroxidases -- 18 Glutathione Peroxidase 4 -- 19 The 15 kDa Selenoprotein: Insights into its regulation and function -- 20 Selenoprotein K and protein palmitoylation in regulating immune cell functions -- 21 Selenoprotein M: Structure, expression and functional relevance -- 22 Selenoprotein P and selenium distribution in mammals -- 23 Selenoprotein T: From discovery to functional studies using conditional knockout mice -- 24 Biochemistry and function of methionine sulfoxide reductase -- Part III. Dietary selenium and its impact on human health -- 25 Selenium: Dietary sources, human nutritional requirements and intake across populations -- 26 Human clinical trials involving selenium -- 27 Status of dietary selenium in cancer prevention -- 28 Selenium in HIV/AIDS -- 29 Genetic variations in the genes for selenoproteins implicate the encoded proteins in cancer etiology -- 30 Is adequate selenium important for healthy human pregnancy? -- 31 The epidemiology of selenium and human health -- 32 Sex-specific differences in biological effects and metabolism of selenium -- 33 Selenium and endocrine tissues -- 34 Selenium antagonism with mercury and arsenic: from chemistry to population health and demography -- 35 Biological selenium species and selenium speciation in biological samples -- 36 Selenoproteins in nervous system development, function and degeneration -- 37 Interplay of selenoproteins and different antioxidant systems in various cancers -- 38 Glutathione peroxidase 2, a selenoprotein exhibiting a dual personality in preventing and promoting cancer -- 39 Selenoproteins in cardiovascular redox pathology -- 40 What do we know about selenium contributions to muscle physiology? -- 41 Tissue-specific regulation of thyroid status by selenodeiodinases -- 42 The role of selenoproteins in resolution of inflammation -- 43 Glutathione peroxidase 4 and ferroptosis -- 44 Mutations in humans that adversely affect the selenoprotein synthesis pathway -- 45 Alteration of selenoprotein expression during stress and in aging -- Part V. Biological models for elucidating the role of selenium and selenoproteins in biology and medicine -- 46 Selenocysteine tRNA[Ser]Sec mouse models for elucidating roles of selenoproteins in health and development -- 47 Mouse models that target individual selenoproteins -- 48 The naked mole rat and selenium -- 49 Glutathione peroxidase 1: Models for diabetes and obesity -- 50 Selenium in livestock and other domestic animals.
520			_aIn the current edition, Selenium: Its Molecular Biology and Role in Human Health expands extensively on the previous editions providing readers with the most significant advances in the rapidly developing selenium field. Evidence from epidemiology and veterinary science supports the essential role of selenium in (human) health, but its split personality in both preventing and supporting cancer and also in promoting insulin resistance has become more clearly defined. The pivotal role of glutathione peroxidase 4 in a new process of programmed cell death, ferroptosis, brings new impetus to the field. Recently defined mutations in selenoprotein and biosynthesis factor genes have been identified in patients, and the resulting disorders further emphasize the significance of selenoproteins in human health. The mechanism of selenoprotein biosynthesis, the functions of selenoproteins, and the roles of dietary selenium have been further elucidated, and new regulatory mechanisms involving selenoproteins discovered. The book, therefore, covers the breadth of current selenium research. With up-to-date chapters written by leaders in their fields, it serves as an invaluable resource for novices as well as specialists.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988	0	0	_aEBOOK, EBSPRINGER
650		7	_aMedicina _0comprobar BNE19900959047 _2embne _9405021
650		7	_aInmunología _0comprobar BNE19900958507 _2embne _9138330
650		7	_aNutrición _0comprobar BNE19900959014 _2embne _9138371
700	1		_aHatfield, Dolph L. _eeditor literario _0Local _984203
700	1		_aSchweizer, Ulrich. _eeditor literario _999790 _0Local
700	1		_aTsuji, Petra A. _eeditor literario _999791 _0Local
700	1		_aGladyshev, Vadim N. _eeditor literario _984205 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-41283-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319412832
907			_a.b12955073 _b10-10-17 _c21-11-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aQP535.S5 S454 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11597306 _z06-04-17
999			_c86229 _d86229 _x1