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001			86208
003			ES-MaUEC
005			20230207040548.0
007			cr nn 008mamaa
008			160822s2016 gw | s |||| 0|eng d
020			_a9783319407937
040			_aES-MaUEC
082	0	4	_a615.19
050		4	_aR853.B54 _bT736 2016 EB
245	1	0	_aTranslating Molecular Biomarkers into Clinical Assays : _bTechniques and Applications _cedited by Russell Weiner, Marian Kelley
264		1	_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XIII, 212 páginas) _b24 ilustraciones, 16 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aAAPS Advances in the Pharmaceutical Sciences Series _x2210-7371 _v21
505	0		_aForeword -- Fit-For-Purpose Validation -- Biomarkers in Drug Discovery and Development: Pre-Analytical and Analytical Considerations -- Biomarker Discovery -- Application of Quantitative Biomeasures in Early Drug Discovery -- Biomarkers in discovery and preclinical phase during drug development -- Incorporating clinical biomarkers into clinical trials -- Perspectives on Tissue Biobanking for Personalized Medicine -- The role of commercial biomarker assay kits in preclinical and clinical trials kits -- Quantification of protein biomarkers using liquid chromatography tandem mass spectrometry -- LC/MS methods for small Molecule biomarkers -- Cell-based Assays -- New Technologies for Cellular Analysis -- Flow cytometry methods for the Clinical Development of Immunomodulatory Biologics -- Key mass spectrometry techniques used in clinical biomarker research -- Clinical Genomic Biomarker Assay Development: Technologies and Issues -- Implementation of Immunohistochemistry assays for clinical trial sample analyses -- Strategic Approach to Outsourcing Clinical Biomarker Assays through CRO Relationships -- In situ hybridization (ISH) in Clinical Biomarker Development. .
520			_aThis handbook covers established and advanced techniques for biomarker analysis, such as guidelines and strategies for assay validation methods; different mathematical models that are necessary in contemporary drug discovery and development; and evaluation of new cytometry methods. Expertly curated by two practicing professionals in drug development and biotherapeutics, individual chapters are selected for novel and sound research; information is chosen based on its relevance to lab applications and clinical trials, such as the topic of selecting animal models for their relevancy to humans. The book is multifaceted, discussing the ethics and issues with biospecimens and providing an in-depth analysis to the differences between pre-clinical and clinical assay development. The book is an essential read for general readers who need an introduction to the history and background of biomarkers, and it also provides critical analyses of various new validation methods for practitioners and researchers. .
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988	0	0	_aEBOOK, EBSPRINGER
650		7	_aMarcadores biológicos _0comprobar BNE20032287302 _2embne _9162047
700	1		_aWeiner, Russell. _eeditor literario _999764 _0Local
700	1		_aKelley, Marian _eeditor literario _0Local _999765
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-40793-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319407937
907			_a.b1295486x _b10-10-17 _c21-11-16
945			_aEBOOK EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11615126 _z30-06-17
998			_aSI _b07/2018 _cm _dz _ea _feng _gxxu _h0
999			_c86208 _d86208 _x1