000			03476nam a22003855i 4500
001			86158
003			ES-MaUEC
005			20230207040545.0
007			cr nn 008mamaa
008			160901s2016 gw | s |||| 0|eng d
020			_a9783319398242
040			_aES-MaUEC
082	0	4	_a571.6
050		4	_aQP188.P26 _bP363 2016 EB
245	1	0	_aPancreatic Islet Isolation : _bFrom the Mouse to the Clinic _cedited by Miriam Ramírez-Domínguez
264		1	_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XII, 123 páginas) _b31 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v938
505	0		_aHistorical Background of Pancreatic Islet Isolation, Miriam Ramírez-Domínguez -- The Different Faces of the Pancreatic Islets, Midhat H.Abdulreda, Rayner Rodriguez-Diaz, Over Cabrera, Alejandro Caicedo, Per-Olof Berggren -- Isolation of Mouse Pancreatic Islets of Langerhans, Miriam Ramírez-Domínguez -- Pancreatic Islets: Methods for Isolation and Purification of Juvenile and Adult Pig Islets, Heide Brandhorst, Paul R.V. Johnson, Daniel Brandhorst -- Isolation of Pancreatic Islets from NonHuman Primates, Dora M. Berman -- Necessities for a Clinical Islet Program, Wayne John Hawthorne -- Clinical Islet Isolation, Wayne John Hawthorne, Lindy Jane Williams, Yi Vee Chew -- Index.
520			_aPancreatic islets make up the endocrine pancreas and they contain the only source of insulin in the body, beta cells. Hence, access to high quality preparations of pancreatic islets is fundamental for in vitro studies and to test pre-clinical applications in animal models in vivo. Access to healthy human islets is also crucial to improve transplantation procedures for diabetes. Given the susceptibility of pancreatic islets to the enzymatic digestion and mechanical stress required to obtain them, the isolation of islets is often considered as the delicate zwork of a craftsmany. This book, which is aimed at beginners and experts alike, is a survey of the current state-of�the-art in this field and it centres on the challenges, pitfalls and peculiarities of pancreatic islet isolation in the different species used in pre-clinical and clinical applications. It explores the similarities and differences between human islets and those from other relevant species (rodents, pigs and non-human primates), and how these influence islet isolation. The ultimate goal of this book is to improve the outcome of islet isolation and transplantation in pre-clinical and clinical applications.
710	2		_aSpringerLink (Online service) _0Local _9106996
830		0	_aMcGraw-Hill's AccessMedicine
942			_2lcc _cLE
988	0	0	_aEBOOK, EBSPRINGER
650		7	_aGlándulas endocrinas _9140308 _0comprobar BNE19900983493 _2embne
700	1		_aRamírez-Domínguez, Miriam. _eeditor literario _999656 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-39824-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319398242
907			_a.b12954366 _b10-10-17 _c21-11-16
945			_aEBOOK EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i1161500x _z30-06-17
998			_aSI _b07/2018 _cm _dz _ea _feng _gxxu _h0
999			_c86158 _d86158 _x1