000			02841nam a22003975i 4500
001			86150
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005			20230207040545.0
007			cr nn 008mamaa
008			160514s2016 gw | s |||| 0|eng d
020			_a9783319396644
040			_aES-MaUEC
050		4	_aQR185.8.I56 _bJ365 2016
082	0	4	_a616.079
100	1		_aJankowski, Marek _0Local _999636
245	1	0	_aInterleukin-27: Biological Properties and Clinical Application _cby Marek Jankowski, Tomasz Wandtke
260			_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (VI, 86 páginas) _b5 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aSpringerBriefs in Immunology _x2194-2773
505	0		_aIL-27: Structure, Regulation and Variability -- IL-27: A Key Player in Immune Regulation -- IL-27 in Health and Disease.
520	3		_aThis volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, asignarmaterias , EBSPRINGER
650		7	_aMedicina _0comprobar BNE19900959047 _2embne _9405021
650		7	_aInmunología _0comprobar BNE19900958507 _2embne _9138330
700	1		_aWandtke, Tomasz _0Local _999637
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-39664-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319396644
907			_a.b12954287 _b10-10-17 _c21-11-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aQR185.8.I56 J365 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11596703 _z06-04-17
999			_c86150 _d86150 _x1