000			04053nam a22003855i 4500
001			86096
003			ES-MaUEC
005			20230207040542.0
007			cr nn 008mamaa
008			161017s2016 gw | s |||| 0|eng d
020			_a9783319388823
040			_aES-MaUEC
050		4	_aQH595 _b.T444 2016
082	0	4	_a572.84
245	1	4	_aThe Functional Nucleus _cedited by David P Bazett-Jones, Graham Dellaire
260			_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (VI, 513 páginas) _b56 ilustraciones, 48 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPart I - Nuclear Periphery -- 1.Laminopathies/Howard Worman -- Part II Nuclear Bodies -- 2.Nucleolus/Marie-Line Dubois and François-Michel Boisvert -- 3.Speckles/splicing and disease/Michael Ladomery and Sebastian Oltean -- 4.PML, cancer and stem cells/Julia P. Hofmann and Paolo Salomoni -- Part III Chromosomes -- 5.Chromosome territories/Karen J. Meaburn, Bharat Burman and Tom Misteli -- 6.Telomeres and Chromosome Instability/Tsz Wai Chu and Chantal Autexier -- PART IV Nuclear Domains and Development -- 7.Polycomb bodies/Vincenzo Pirrotta -- 8.Ikaros domains/Karen E. Brown -- PART V Nuclear Domains and Cell Stress -- 9.Senescence/SAHFs/Tamir Chandra -- 10.DNA repair foci as facultative nuclear domains/Michael J. Hendzel and Hilmar Strickfaden -- 11.DNA damage and the nucleus/Jordan Pinder, Anastazja Grabarz, Evi Soutoglou and Graham Dellaire -- 12.Inflammation and the nucleus/Sona Hubackova , Simona Moravcova and Zdenek Hodny -- 13.Viral infection and the nucleus/Lori Frappier -- PART VI Macromolecular dynamics within the nucleus -- 14.Actin filaments/motors/Guillaume Huet and Maria K. Vartiainen -- 15.Molecular diffusion/Alexander Gansen and Jörg Langowski -- PART VII Chromatin transactions and epigenetics -- 16.Fibres/interactions/Christopher J.F. Cameron, James Fraser, Mathieu Blanchette, and Josée Dostie -- 17.DNA replication Sebastian Müller, Dan Filipescu and Geneviève Almouzni -- 18.Development and Epigenetics Nuphar Salts and Eran Meshorer -- 19.Epigenetics and disease/Sanaa Choufani and Rosanna Weksberg -- PART VIII Transcription and RNA metabolism -- 20.Transcription factories/Christopher Eskiw and Jenifer Mitchell -- 21.RNA transport Jonathan Sheinberger and Yaron Shav-Tal. .
520	3		_aThis book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, asignarmaterias , EBSPRINGER
650	0	4	_9495993 _aCiencias de la vida
650		7	_aCitogenética _0comprobar BNE19900974673 _2embne _9139622
700	1		_aBazett-Jones, David P. _eeditor literario _999530 _0Local
700	1		_aDellaire, Graham _eeditor literario _0Local _999531
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-38882-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319388823
907			_a.b1295374x _b10-10-17 _c21-11-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h4
945			_aQH595 .T444 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11596211 _z06-04-17
999			_c86096 _d86096 _x1