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001			86084
003			ES-MaUEC
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008			160823s2016 gw | s |||| 0|eng d
020			_a9783319350721
040			_aES-MaUEC
050		4	_aQP552.M44 _bT446 2016
082	0	4	_a572.6
245	1	4	_aThe Next Generation in Membrane Protein Structure Determination _cedited by Isabel Moraes
260			_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (X, 184 páginas) _b73 ilustraciones, 64 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v922
505	0		_aExpression Screening of Integral Membrane Proteins by Fusion to Fluorescent Reporters -- Detergents in Membrane Protein Purification and Crystallisation -- NMR of Membrane Proteins: Beyond Crystals -- Characterisation of Conformational and Ligand Binding Properties of Membrane Proteins Using Synchrotron Radiation Circular Dichroism (SRCD) -- Membrane Protein Crystallization: Current Trends and Future Perspectives -- Crystal Dehydration in Membrane Protein Crystallography -- Nonlinear Optical Characterization of Membrane Protein Microcrystals and Nanocrystals -- Exploiting Microbeams for Membrane Protein Structure Determination -- Applications of the BLEND Software to Crystallographic Data from Membrane Proteins -- Serial Millisecond Crystallography of Membrane Proteins -- Serial Femtosecond Crystallography of Membrane Proteins -- Beyond Membrane Protein Structure: Drug Discovery, Dynamics and Difficulties.
520	3		_aThis book reviews current techniques used in membrane protein structural biology, with a strong focus on practical issues. The study of membrane protein structures not only provides a basic understanding of life at the molecular level but also helps in the rational and targeted design of new drugs with reduced side effects. Today, about 60% of the commercially available drugs target membrane proteins and it is estimated that nearly 30% of proteins encoded in the human genome are membrane proteins. In recent years much effort has been put towards innovative developments to overcome the numerous obstacles associated with the structure determination of membrane proteins. This book reviews a variety of recent techniques that are essential to any modern researcher in the field of membrane protein structural biology. The topics that are discussed are not commonly found in textbooks. The scope of this book includes: Expression screening using fluorescent proteins The use of detergents in membrane protein research The use of NMR Synchrotron developments in membrane protein structural biology Visualisation and X-ray data collection of microcrystals X-ray diffraction data analysis from multiple crystals Serial millisecond crystallography Serial femtosecond crystallography Membrane protein structures in drug discovery The information provided in this book should be of interest to anyone working in the area of structural biology. Students will find carefully prepared overviews of basic ideas and advanced protein scientists will find the level of detail required to apply the material directly to their day to day work.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, asignarmaterias , EBSPRINGER
650	0	4	_9495993 _aCiencias de la vida
650		7	_aProteínas _0comprobar BNE19900977845 _2embne _9139861
700	1		_aMoraes, Isabel. _eeditor literario _999515 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-35072-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319350721
907			_a.b12953623 _b10-10-17 _c21-11-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h4
945			_aQP552.M44 T446 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11596107 _z06-04-17
999			_c86084 _d86084 _x1