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008			160729s2016 gw | s |||| 0|eng d
020			_a9783319341750
040			_aES-MaUEC
050		4	_aQP620 _b.M635 2016
082	0	4	_a611.01816
082	0	4	_a599.935
245	1	0	_aModified Nucleic Acids in Biology and Medicine _cedited by Stefan Jurga, Volker A Erdmann (Deceased), Jan Barciszewski
260			_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XIV, 453 páginas) _b122 ilustraciones, 46 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aRNA Technologies _x2197-9731
505	0		_aTransfer RNA Modifications: from Biological Functions to Biomedical Applications -- Regulated tRNA Cleavage in Biology and Medicine: Roles of tRNA Modifications -- Sulfur-Modifications in tRNA: Function and Implications for Human Disease -- Regulation of Protein Synthesis via the Network Between Modified Nucleotides in tRNA and tRNA Modification Enzymes in Thermus thermophilus, Athermophilic Eubacterium -- Post-Transcriptional Modifications of RNA: Impact on RNA Function and Human Health -- RNA Modification N6-methyladenosine in Post-Transcriptional Regulation -- 8-Hydroxyguanine, an Oxidative DNA and RNA Modification -- Methods for Determination of 2�-O-Me in RNA -- DiadenosineTetraphosphate (Ap4A), in Health and Disease -- Thinking Small: Circulating MicroRNAs as Novel Biomarkers for Diagnosis, Prognosis and Treatment Monitoring in Breast Cancer -- Modified Antisense Oligonucleotides and their Analogs in Therapy of Neuromuscular Diseases -- Effect of Depurination on Cellular and Viral RNA -- Recognition of RNA Sequence and Structure by Duplex and Triplex Formation: Targeting miRNA and pre-miRNA -- Modifications in Therapeutic Oligonucleotides Improving the Delivery -- Interstrand Cross-Linking of Nucleic Acids: from History Towards Recent and Future Applications -- Chemical Synthesis of Lesion-Containing Oligonucleotides for DNA-Repair Studies -- Single-Molecule Visualization of Biomolecules in the Designed DNA Origami Nanostructures Using High-Speed Atomic Force Microscopy -- Polymerase Reactions that Involve Modified Nucleotides.
520	3		_aThis volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression. Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides. This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology. .
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, asignarmaterias , EBSPRINGER
650		7	_aMedicina _0comprobar BNE19900959047 _2embne _9405021
650		7	_aGenética humana _0comprobar BNE19900986777 _2embne _9140562
700	1		_aJurga, Stefan. _eeditor literario _993804 _0Local
700			_aErdmann, Volker _eeditor literario _0Local _985268
700	1		_aBarciszewski, Jan. _eeditor literario _985269 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-34175-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319341750
907			_a.b12953519 _b10-10-17 _c21-11-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aQP620 .M635 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11596028 _z06-04-17
999			_c86073 _d86073 _x1