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020			_a9783319307053
040			_aES-MaUEC
050		4	_aRB170 _b.R436 2016
082	0	4	_a571.9453
245	1	0	_aRedox-Active Therapeutics _cedited by Ines Batinic-Haberle, Júlio S Rebouças, Ivan Spasojevic
260			_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XXX, 694 páginas) _b162 ilustraciones, 124 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aOxidative Stress in Applied Basic Research and Clinical Practice _x2197-7224
505	0		_aPart 1. Pathophysiological Roles of Superoxide Dismutases (SOD) -- Superoxide and the Superoxide Dismutases: An Introduction by Irwin Fridovich -- The Discovery of Superoxide Dismutase and Its Role in Redox Biology -- Manganese Superoxide Dismutase (MnSOD) and It's Importance in Mitochondrial Function and Cancer -- Regulation of the Cellular Redox Environment by Superoxide Dismutases, Catalase and Glutathione Peroxidases During Tumor Metastasis -- Superoxide Dismutase Family of Enzymes in Brain Neurogenesis and Radioprotection -- Metabolic Production of H2O2 in Carcinogenesis and Cancer Treatment -- Part 2. Redox-Active Therapeutics � Design and Mechanisms of Action -- Mimicking SOD, Why and How: Bio-Inspired Manganese Complexes as SOD Mimics -- Mn Porphyrin-Based Redox-Active Therapeutics -- Cytochrome P450-like Biomimetic Oxidation Catalysts Based on Mn porphyrins as Redox Modulators -- Nitrones as Potent Anticancer Therapeutics -- Salen Manganese Complexes Mitigate Radiation Injury in Normal Tissues Through Modulation of Tissue Environment -- Molecular Basis for Anticancer and Antiparasite Activities of Copper-Based Drugs -- Small Signaling Molecules and CO-Releasing Molecules (CORMs) for the Modulation of the Cellular Redox Metabolism -- HNO/Thiol Biology as a Therapeutic Target -- Part 3. Redox-Active Therapeutics in Cancer -- Advances in Breast Cancer Therapy Using Nitric Oxide and Nitroxyl Donor Agents -- Mechanisms by Which Manganese Porphyrins Affect Signaling in Cancer Cells -- Targeted Therapy for Malignant Brain Tumors -- Redox Therapeutics in Breast Cancer: Role of SOD Mimics -- Anticancer Action of Mn porphyrins in Head and Neck Cancers -- Redox-based Therapeutic Strategies in the Treatment of Skin Cancers -- Role of Oxidative Stress in Erectile Dysfunction after Prostate Cancer Therapy -- Theranostic Nanoconjugates of Tetrapyrrolic Macrocycles and Their Applications in Photodynamic Therapy -- Part 4. Redox-Active Therapeutics in Other Diseases -- Quantum Dots in Photodynamic Therapy -- Metalloporphyrins in CNS injuries -- The Contribution of Nitroxidative Stress to Pathophysiological Pain and Opioid Analgesic Failure -- Amyotrophic Lateral Sclerosis � Present Understanding of the Role of SOD -- Redox Regulation and Misfolding of SOD1: Therapeutic Strategies for Amyotrophic Lateral Sclerosis -- Redox-Based Therapeutics for Prevention, Mitigation, and Treatment of Lung Injury Secondary to Radiation Exposure -- Using Metalloporphyrins to Preserve Ý Cell Mass and Inhibit Immune Responses in Diabetes -- Redox-Active Metal Complexes in Trypanosomatids.
520	3		_aThis essential volume comprehensively discusses redox-active therapeutics, focusing particularly on their molecular design, mechanistic, pharmacological and medicinal aspects. The first section of the book describes the basic aspects of the chemistry and biology of redox-active drugs and includes a brief overview of the redox-based pathways involved in cancer (such as the role of mitochondria, hydrogen peroxide and endogenous antioxidative defenses) and the medical aspects of redox-active drugs, assuming little in the way of prior knowledge. The second section encompasses several major classes of redox-active experimental therapeutics, which include porphyrins, salens, nitrones, and other metal-containing (e.g., Mn, Fe, Cu, Zn, Sb) drugs as either single compounds or formulations with nanomaterials and quantum dots. Subsequent sections and chapters describe more specialized aspects of redox-active therapeutics in clinical disorders, such as cancer, cardiovascular diseases, diabetes, central nervous system injuries, neurodegenerative diseases, pain, radiation injury and radioprotection (such as of brain, lungs, head and neck and erectile function) and neglected diseases (e.g., leishmaniasis). Numerous illustrations, tables and figures enhance and complement the text; extensive references to relevant literature are also included. Redox-Active Therapeutics is an invaluable addition to Springer�s Oxidative Stress in Applied Basic Research and Clinical Practice series. It is essential reading for researchers, clinicians and graduate students interested in understanding and exploring the Redoxome�the organism redox network�as an emerging frontier in drug design, redox biology and medicine.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, asignarmaterias , EBSPRINGER
650	0	4	_9495993 _aCiencias de la vida
650		7	_aCáncer _xInvestigación _0comprobar BNE19901364217 _2embne _9182523
700	1		_aBatinic-Haberle, Ines _eeditor literario _0Local _998933
700	1		_aRebouças, Júlio S. _eeditor literario _998934 _0Local
700	1		_aSpasojevic, Ivan. _eeditor literario _998935 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-30705-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319307053
907			_a.b12950312 _b10-10-17 _c21-11-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aRB170 .R436 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i1159343x _z06-04-17
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