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008			160519s2016 gw | s |||| 0|eng d
020			_a9783319305677
040			_aES-MaUEC _bspa
050		4	_aQL966 _b2016 EB
082	0	4	_a612
245	1	0	_aSperm Acrosome Biogenesis and Function During Fertilization _cedited by Mariano G Buffone
264		1	_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (VII, 172 páginas) _b19 ilustraciones, 16 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aAdvances in Anatomy, Embryology and Cell Biology _x0301-5556 _v220
505	0		_aPreface -- The acrosome reaction: a historical perspective -- The acrosomal matrix -- Role of ion channels in the sperm acrosome reaction -- The molecules of sperm exocytosis -- Sperm capacitation and acrosome reaction in mammalian sperm -- Lipid regulation of acrosome exocytosis -- Role of actin cytoskeleton during mammalian sperm acrosomal exocytosis -- Site of mammalian sperm acrosome reaction.
520			_aOver the last decades, acrosomal exocytosis (also called the zacrosome reactiony) has been recognized as playing an essential role in fertilization. Secretion of this granule is an absolute requirement for physiological fertilization. In recent years, the study of mammalian acrosomal exocytosis has yielded some major advances that challenge the long-held, general paradigms in the field. Principally, the idea that sperm must be acrosome-intact to bind to the zona pellucida of unfertilized eggs, based largely on in vitro fertilization studies of mouse oocytes denuded of the cumulus oophorus, has been overturned by experiments using state-of-the-art imaging of cumulus-intact oocytes and fertilization experiments where eggs were reinseminated by acrosome-reacted sperm recovered from the perivitelline space of zygotes. From a molecular point of view, acrosome exocytosis is a synchronized and tightly regulated process mediated by molecular mechanisms that are homologous to those reported in neuroendocrinal cell secretions. The authors provide a broader perspective, focusing on a limited number of important topics that are essential for understanding the molecular mechanisms governing this step in the fertilization process. They also discuss molecular aspects such as the signaling pathways leading to exocytosis, including the participation of ion channels, lipids, the fusion machinery proteins and the actin cytoskeleton as well as cellular aspects such as the site of acrosomal exocytosis and the use of gene-manipulated animals to study this process. .
650		7	_aEspermatogénesis _9666055 _2embne
700	1		_aBuffone, Mariano G. _eeditor literario _998911 _0Local _0http://id.loc.gov/authorities/names/nb2016013596 _1http://viaf.org/viaf/89146822214007381215
710	2		_aSpringerLink (Online service) _0Local _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-30567-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319305677
907			_a.b12950130 _b10-10-17 _c21-11-16
942			_2lcc _cLE
945			_aEBOOK EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11614286 _z30-06-17
988			_aSpringer_Medicine_2016
998			_aSI _a_alco _a_vill _b10/2018 _cm _dz _ek _feng _ggw _h0
999			_c85735 _d85735 _x1