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008			160621s2016 gw | s |||| 0|eng d
020			_a9783319302737
040			_aES-MaUEC
050		4	_aRM370 _b.K436 2016
082	0	4	_a615
100	1		_aKhan, Manzoor M. _998833 _0Local
245	1	0	_aImmunopharmacology _cby Manzoor M Khan
250			_a2nd ed.
260			_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XIX, 442 p.) _b71 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aOverview of the Immune Response -- Role of Cytokines -- Cytokine Receptors and Signaling -- Immunosuppressive Agents -- Monoclonal Antibodies as Therapeutic Agents -- Allergic Disease -- Tissue Transplantation -- Acquired Immune Deficiency Syndrome -- Regulatory T Cells and Disease State -- Gene Therapy.
520			_aThe concept of immunotherapy was in infancy when the first edition was written; since then, major advances have been made, not only with several prominent clinical trials, but also with the approval of cell-based therapy by the FDA for the treatment of cancer in 2010. These events resulted in a gradually narrowing gap between early scientific knowledge and the late development of immune-based therapies. Consequently, the significance and magnitude of these advances warranted a revision of this contribution; this revised edition will provide a deeper understanding of the recent advances and discoveries related to the function of the immune response and their applications in the development of novel therapies to treat human diseases. Some of the key discoveries during the past five years include: the identification of the new subsets of helper T cells; new cytokines and their networks; and novel signal transduction mechanisms. For example, the identification of TH17 subset of helper T cells, in addition to TH1 and TH2 cells, not only advanced our understanding of the function of the basic immune response, but also raised our awareness of the possible etiology and pathogenesis of diseases such as allergy, asthma, rheumatoid arthritis, and other auto-immune/immune system based diseases. The newly identified powerful cytokine networks, that regulate both innate and acquired immune responses, emerged as a result of the finding of new cell types such as innate lymphoid cells and iNKT. Identification of the novel cytokines and their networks has advanced our knowledge of the mechanisms involved in the maintenance of tissue homeostasis, including inflammation and tissue repair during stress and injury. The development of HIV vaccines has also seen dramatic changes over the last few years. There has been a shift from a sole focus on T cell vaccines to a holistic approach that pertains to the induction of both humoral and cellular elements. This entails the induction of antibodies � both binding and neutralizing � to prevent infection. The cellular vaccination produces a safety net of CD8+ T-cell responses to suppress the replication of the virus in the infected patients, and both of the effector arms are aided by helper T cells. From the perspective of clinical applications, significant advances have also been made in: oral immunotherapy for allergic disease, the possible treatment of HIV infection, the development of new monoclonal antibodies and their fragments to treat human diseases, and immune cell based therapies for cancer. .
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988	0	0	_aEBOOK, EBSPRINGER
650		7	_aMedicina _0comprobar BNE19900959047 _2embne _9405021
650		7	_aGenética humana _0comprobar BNE19900986777 _2embne _9140562
650		7	_aFisiología humana _0comprobar BNE19900979803 _2embne _9140024
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-30273-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319302737
907			_a.b12949723 _b10-10-17 _c21-11-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aRM370 .K436 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11592928 _z06-04-17
999			_c85694 _d85694 _x1