000			03933nam a22004335i 4500
001			85660
003			ES-MaUEC
005			20230207040521.0
007			cr nn 008mamaa
008			160817s2016 gw a s 001 0 eng d
020			_a9783319300795
024	7		_a10.1007/978-3-319-30079-5 _2doi
040			_aES-MaUEC
050		4	_aQH603 _b2016 EB
082	0	4	_a616.079
245	0	0	_aAutophagy Networks in Inflammation _cedited by Maria Chiara Maiuri, Daniela De Stefano
264		1	_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XV, 403 p.) _b20 ilustraciones, 16 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aProgress in Inflammation Research
505	0		_aAutophagy in direct pathogen elimination (Xenophagy) -- Autophagy and pattern recognition receptors -- Autophagy and inflammasomes -- Autophagy and Antigen presentation -- Autophagy and regulation of T and B cell function -- Autophagy in chronic inflammation -- The complex crosstalk between autophagy and ROS -- Lipophagy -- Autophagy, phagocytosis and entosis: who eats whom?- Which is the cell fate of inflammatory cells ? Autophagic cell death, pyroptosis, netosis, apoptosis, necrosis -- Host defence (virus/bacteria) -- Neurological diseases -- Pulmonary diseases (emphysema, COPD, etc.) -- Inflammatory bowel disease -- Target autophagy as a novel therapeutic strategy in autoimmune diseases -- Liver and pancreatic diseases -- Obesity -- Aging -- Overview on clinical trials.
520	3		_aAutophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pathway in immunity and inflammation. Moreover, direct interactions between autophagy proteins and immune signalling molecules have also been demonstrated. Defects in autophagy - similar to cancer, neurodegenerative diseases and aging - through autophagy gene mutation and/or microbial antagonism, may underlie the pathogenesis of many infectious diseases and inflammatory syndromes. In spite of the increasing awareness of the importance of autophagy in these pathophysiological conditions, this process remains underestimated and is often overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these diseases are still poorly understood. This book reviews the recent advances regarding the functions of the autophagy pathway and autophagy proteins in immunity and inflammation, focusing on their role in self-nonself distinction, their implications in innate and adaptive immune responses and their dysregulation in the pathology of certain inflammatory and autoimmune diseases.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
650		7	_aMembranas celulares _0comprobar BNE19901012138 _2embne _9142266
650		7	_aCitología _0comprobar BNE19900972907 _2embne _9139477
650		7	_aEnfermedades infecciosas _0comprobar BNE19900959429 _2embne _9138404
700	1		_aMaiuri, Maria Chiara _0n 2016190118 _eeditor literario _948598
700	1		_aDe Stefano, Daniela, _0n 2016190120 _eeditor literario _948599
830		0	_aProgress in Inflammation Research _9133340
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-30079-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319300795
907			_a.b12949383 _b11-11-17 _c21-11-16
988			_aSpringer_Medicine_2016
998			_am _a_alco _a_vill _b11-11-17 _cm _dz _ei _feng _ggw _h0
945			_aQH603 .A98 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11592643 _z06-04-17
999			_c85660 _d85660 _x1