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020			_a9783319296357
040			_aES-MaUEC
050		4	_aQH603.I54 _bV373 2016
082	0	4	_a612
245	1	0	_aVascular Ion Channels in Physiology and Disease _cedited by Irena Levitan, PhD, Alex M Dopico, MD, PhD
260			_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XVII, 431 páginas) _b103 ilustraciones, 75 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aForeword -- Endothelial cell ion channel expression and function in arterioles and resistance arteries -- Contribution and Regulation of Calcium channels in Endothelial Cells -- Mitochondrial depolarization in endothelial and other vascular cells and their role in the regulation of cerebral vascular tone -- Ion channels in Hypertension and Control of Blood Flow: Electrical conduction along endothelium of resistance arteries -- Ca2+/calmodulin-gated small- and intermediate-conductance KCa channels in cardiovascular regulation: Targets for novel pharmacological treatments -- Regional Variation in Arterial Myogenic Responsiveness - Links to Potassium Channel Diversity/Function -- Ion Channel Trafficking and Control of Arterial Contractility -- Abnormalities of Vascular Ion Channels during Hypertension -- Kv7 Potassium Channels as Therapeutic Targets in Cerebral Vasospasm -- Lysosomal Transient Receptor Potential Mucolipin (TRPML) Channels in Vascular Regulation and Diseases -- Calcium Mobilization via Intracellular Ion Channels, Store Organization and Mitochondria in Smooth Muscle -- Role of mechanosensitive TRP channels in Abnormal Vasculature of Tumors -- TRPC and Orai channels in store-operated calcium entry and vascular remodeling -- Smooth muscle cell ion channels in pulmonary arterial hypertension: pathogenic role in pulmonary vasoconstriction and vascular remodeling -- Physiological roles and cholesterol sensitivity of endothelial inwardly-rectifying K+ channels: specific cholesterol-protein interactions through non annular binding sites -- Membrane lipids and regulation of smooth muscle ion channels -- Transient receptor potential channels in metabolic syndrome-induced coronary artery disease -- Mitochondrial ion channels in metabolic disease -- Index.
520	3		_aIon channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions. Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes. In addition, misregulated angiogenesis is one of the major contributors to the development of tumors. Therefore, it is clearly imperative to obtain a better understanding of the molecular mechanisms that contribute to vascular disorders. This book will be the first comprehensive assembly of assays to present the studies that have been done during the last decade to elucidate the roles of ion channels in different vascular diseases.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, asignarmaterias , EBSPRINGER
650		7	_aMedicina _0comprobar BNE19900959047 _2embne _9405021
650		7	_aFisiología humana _0comprobar BNE19900979803 _2embne _9140024
700	1		_aLevitan, Irena _eeditor literario _0Local _998695
700	1		_aDopico, Alex M. _eeditor literario _0Local _998696
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-29635-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319296357
907			_a.b12948743 _b10-10-17 _c21-11-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aQH603.I54 V373 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11592114 _z06-04-17
999			_c85596 _d85596 _x1