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001			85486
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008			160608s2016 gw | s |||| 0|eng d
020			_a9783319286372
040			_aES-MaUEC
050		4	_aRC365 _b2016 EB
082	0	4	_a616.8
245	1	0	_aMitochondrial Dysfunction in Neurodegenerative Disorders _cedited by Amy K Reeve, Eve M Simcox, Michael R Duchen, Doug M Turnbull
250			_a2nd ed.
260			_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XI, 380 p.) _b34 ilustraciones, 29 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPart I. Mitochondria and Neurodegenerative Disease -- An Introduction to Mitochondria, Their Structure and Functions -- Part II. Mitochondrial Dysfunction: Causes and Effects? -- Neurodegeneration in Mitochondrial Disorders -- The Ageing Brain, Mitochondria and Neurodegeneration -- Mitochondrial Genes and Neurodegenerative Disease -- Mitochondrial Signalling and Neurodegeneration -- Part III. Functional Consequences of Mitochondrial Dysfunction -- Life on the Edge: Determinants of Selective Neuronal Vulnerability in Parkinson's Disease -- Mitochondrial Dynamics and Neurodegeneration -- Mitochondrial Dysfunction and Transport in Demyelinating Disease with Inflammation -- Mitochondria, the Synapse, and Neurodegeneration -- Protein Misfolding and Aggregation: Implications for Mitochondrial Dysfunction and Neurodegeneration -- Mitochondrial Degradation, Autophagy and Neurodegenerative Disease -- The Deleterious Duo of Neurodegeneration: Lysosomes and Mitochondria -- Part IV. Measuring the Contribution of Mitochondrial Dysfunction to Neurodegenerative Disease -- Can We Accurately Model Mitochondrial Dysfunction in Neurodegeneration? -- Mitochondrial Function and Dynamics Imaged In Vivo -- Part V. The Future -- Development of Treatments and Therapies to Target Mitochondrial Dysfunction -- Summary and Conclusions
520	3		_aThis second edition brings together up-to-date contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease and multiple sclerosis. The reader is guided through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, and on to the consequences of this dysfunction for neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets. Additional chapters have been added to the book to reflect advances in the field and there are many new contributors and topics, including how mitochondria are degraded and the interaction of the mitochondria with pathologically relevant proteins. Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
650		7	_aSistema nervioso _xDegeneración _9313064 _0comprobar BNE20012072191 _2embne
650		7	_aNeurociencias _0comprobar BNE20012490612 _2embne _9158907
650		7	_aMedicina interna _0comprobar BNE19900959227 _2embne _9138387
700	1		_aReeve, Amy K. _eeditor literario _998475 _0Local
700	1		_aSimcox, Eve M. _eeditor literario _998476 _0Local
700	1		_aDuchen, Michael R. _eeditor literario _998477 _0Local
700	1		_aTurnbull, Doug M. _eeditor literario _998478 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-28637-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319286372
907			_a.b12947647 _b10-10-17 _c21-11-16
988			_aSpringer_Medicine_2016
998			_am _a_alco _a_vill _b19-06-17 _cm _dz _ek _feng _ggw _h0
945			_aRC365 .M586 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11591183 _z06-04-17
999			_c85486 _d85486 _x1