000			03187nam a22003975i 4500
001			85376
003			ES-MaUEC
005			20240611040143.0
007			cr nn 008mamaa
008			160209s2016 gw | s |||| 0|eng d
020			_a9783319278209
040			_aES-MaUEC
050		4	_aRD651 _b.R53 2016 EB
082	0	4	_a614.5999
100	1		_aRibatti, Domenico. _986304 _0Local _1http://viaf.org/viaf/102495071
245	1	4	_aThe Role of Microenvironment in the Control of Tumor Angiogenesis _cby Domenico Ribatti
250			_a1st ed.
264		1	_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XI, 86 páginas) _b28 ilustraciones, 12 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPrelims -- Tumor microenvironment -- Tumor blood vessels and tumor endothelial cells -- Tumor angiogenesis -- Inflammatory cells in tumor microenvironment -- Therapeutic strategies, the concept of znormalizationy and the role of VEGF inhibition -- Index. .
520			_aThis work describes the importance of tumor microenvironment in favouring tumor progression and angiogenesis. Under physiological conditions, angiogenesis is dependent on the balance of positive and negative angiogenic modulators within the vascular microenvironment and requires the functional activities of a number of molecules, including angiogenic factors, extracellular matrix proteins, adhesion molecules and proteolytic enzymes. In normal tissues, vascular quiescence is maintained by the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli. Tumor angiogenesis is linked to a switch in the balance between positive and negative regulators, and mainly depends on the release by inflammatory or neoplastic cells of specific growth factors for endothelial cells, that stimulate the growth of the blood vessels of the host or the down-regulation of natural angiogenesis inhibitors. In particular, the inflammatory infiltrate may contribute to tumor angiogenesis, and there are many reports of associations between tumor inflammatory infiltrate, vascularity and prognosis. New therapeutic approaches have been developed with the aim to control tumor angiogenesis through targeting of different components of tumor microenvironment.
650		7	_aCáncer _xInvestigación _2embne _9182523
650		7	_aOncología _2embne _9139207
710	2		_aSpringerLink (Online service) _0Local _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-27820-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319278209
907			_a.b12946540 _b10-10-17 _c21-11-16
942			_2lcc _cLE
945			_aEBOOK EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i1161366x _z30-06-17
988	0	0	_aEBOOK, EBSPRINGER, GOBI_sep2018
988			_aEbook_one2one
998			_aSI _a_alco _a_vill _b10/2018 _cm _dz _ef _feng _ggw _h4
999			_c85376 _d85376 _x1