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001			85264
003			ES-MaUEC
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008			160509s2016 gw | s |||| 0|eng d
020			_a9783319269740
040			_aES-MaUEC
050		4	_aQP535.C2 _bC353 2016
082	0	4	_a571.6
245	1	0	_aCalcium Entry Pathways in Non-excitable Cells _cedited by Juan A Rosado
260			_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (X, 471 páginas) _b36 ilustraciones, 34 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v898
505	0		_aHistorical overview of store-operated Ca2+ entry -- The STIM1- Orai interaction -- The TRPCs, Orais and STIMs in ER/PM junctions -- The TRP-Na-Ca2+ exchanger coupling -- Role of TRPC channels in store-operated calcium entry -- Phospholipase A2 as a molecular determinant of store-operated calcium entry -- Extracellular calcium has multiple targets to control cell proliferation -- Regulation of platelet function by Orai, STIM and TRP -- On the roles of the Transient Receptor Potential Canonical 3 (TRPC3) channel in endothelium and macrophages: implications in atherosclerosis -- Second messenger-operated calcium entry through TRPC6 -- Transient Receptor Potential Canonical 7 (TRPC7), a Calcium (Ca2+) Permeable Nonselective Cation Channel -- Calcium entry through thermosensory channels -- Calcium signalling through ligand-gated ion channels such as P2X1 receptors in the platelet and other non-excitable cells -- The calcium entry-calcium refilling coupling -- Microdomains associated to lipid rafts -- Role of scaffolding proteins in the regulation of TRPC-dependent calcium entry -- Modulation of calcium entry by mitochondria -- Modulation of calcium entry by the endo-lysosomal system -- Remodeling of calcium entry pathways in cancer.
520	3		_aCalcium entry pathways in non-excitable cells presents a concise synthesis of thoughtfully selected topics covering from the different calcium entry mechanisms in non-excitable cells to the cellular microdomains and organelles regulating the calcium entry process. Particular attention is given to the fascinating group of ion channels involved in different calcium entry pathways as well as the emerging role of these channels in human disease. Calcium entry is an essential mechanism for cellular function in non-excitable cells. In general, two main calcium entry pathways exist in non-excitable cells: one pathway, named store-operated calcium entry (SOCE) requires store depletion and the second pathway is regulated by receptor occupation, but independently on calcium store depletion. The search for the molecular components of calcium entry has identified the stromal interaction molecule 1 (STIM1), as the calcium sensor of the intracellular calcium stores, and Orai as well as TRP channels as the calcium-permeable channels located in the plasma membrane. The location, interactions and function of these channels are finely regulated by a number of scaffolding proteins, membrane microdomains and cellular organelles that fine tune the amount of calcium entering the cell. Cutting-edge and user-friendly, this volume presents relevant background information, critical analysis of the current observations and directions for future research. The book is intended for basic scientists specializing in cellular biology or ion transport, as well as for biomedical researchers.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, asignarmaterias , EBSPRINGER
650	0	4	_9495993 _aCiencias de la vida
650		7	_aFisiología humana _0comprobar BNE19900979803 _2embne _9140024
700	1		_aRosado, Juan A. _eeditor literario _946955 _0comprobar XX5415521
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-26974-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319269740
907			_a.b12945420 _b10-10-17 _c21-11-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aQP535.C2 C353 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11589310 _z06-04-17
999			_c85264 _d85264 _x1