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999			_c85168 _d85168 _x1
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003			ES-MaUEC
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007			cr nn 008mamaa
008			151226s2016 gw a s 0|1 0 eng d
020			_a9783319261331
024	7		_a10.1007/978-3-319-26133-1 _2doi
040			_aES-MaUEC
050		4	_aQR185.8.B15 _bB34 2016 EB
082	0	4	_a616.079
245	0	0	_aB Cell Receptor Signaling _cedited by Tomohiro Kurosaki, Jürgen Wienands
250			_a1st ed. 2016
260			_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (VIII, 231 p.)
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aCurrent Topics in Microbiology and Immunology _x0070-217X _v393
505	0		_aAssembly and function of the precursor B-cell receptor -- Receptor Dissociation and B cell activation -- Molecular mechanisms of B cell antigen gathering and endocytosis -- BTK signaling in B cell differentiation and autoimmunity -- The memory function of the B cell antigen receptor -- PI3K signaling in normal B cells and chronic lymphocytic leukemia (CLL) -- Role of Calcium Signaling in B Cell Activation and Biolog -- Roles of the NF-kappaB pathway in B-lymphocyte biology -- MAP kinase cascades in antigen receptor signaling and physiology.
520			_aThis volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton's Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases
650	0	7	_aCélulas sanguíneas _9160868 _2embne
650		7	_aInmunología _0comprobar BNE19900958507 _2embne _9138330
700	1		_aKurosaki, Tomohiro _eeditor literario _997904 _0Local
700	1		_aWienands, Jürgen _eeditor literario _997905 _0Local
710	2		_aSpringerLink (Online service) _0Local _9106996
830		0	_aCurrent Topics in Microbiology and Immunology _x0070-217X _v393 _9133248
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-26133-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319261331
907			_a.b12944464 _b10-10-17 _c21-11-16
942			_2lcc _cLE
945			_aQR185.8.B15 B34 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11588512 _z06-04-17
988			_aEBOOK, EBSPRINGER
998			_am _a_alco _a_vill _b09-09-17 _cm _dz _ei _feng _ggw _h0