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008			151228s2016 gw a s 001 0 eng d
020			_a9783319256931
024	7		_a10.1007/978-3-319-25693-1 _2doi
040			_aES-MaUEC
050		4	_aRC343.3 _bN548 2016
082	0	4	_a612.8
100	1		_aNieuwenhuys, Rudolf _d1927- _0BNE19924707187 _915465
245	1	0	_aTowards a New Neuromorphology _cby Rudolf Nieuwenhuys, Luis Puelles
250			_a1st ed.
264		1	_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XV, 344 p.) _b133 ilustraciones, 95 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_a 1. From classic to modern neuromorphology, an introductory overview -- 2. The neural plate -- 3. From neural plate to neural tube -- 4. The neural tube -- 5. The axis of the brain, its flexures and correlates -- 6. The (complex) rostral part of the brain -- Summary -- 7. The natural coordinate system of the CNS -- 8. The fundamental morphological units (FMUs) of the CNS -- 9. The structural pattern, 'Bauplan' or {u2018}blueprint' of the CNS -- 10. The development of grisea -- 11. The {u2018}wiring' of the brain -- 12. General summary, conclusions and perspective -- References -- Index.
520	3		_aThis book demonstrates that the systematic study of gene expression patterns in embryonic and adult brains, in combination with selected data from earlier studies, can pave the way for a new neuromorphology, the most salient features of which may be summarized as follows: (1) Causal analysis of molecular patterning at neural plate and early neural tube stages has shown that the CNS is essentially organized into transverse neural segments or neuromeres and longitudinal zones which follow the curved axis of the brain. (2) The FMUs initially represent thin neuroepithelial fields; in the course of further development they are transformed into three-dimensional radial units, extending from the ventricular surface to the meningeal surface of the brain. (3) The principal histogenetic processes, including cellular proliferation, cell migration and differentiation, essentially take place within the confines of these radial units, controlled by characteristic sets of developmental regulatory genes. (4) Although most developing neurons migrate radially and settle within their own FMU, at many locations neuroblasts leave the FMU where they were produced and migrate tangentially to other nearby or remote territories, colonizing parts of foreign FMUs. (5) Many structural complexes in the adult brain, including the cerebral and cerebellar cortices, are the products of radial and tangential intermingling of migrated cell contingents. (6) By using appropriate molecular markers, all neuron types in the adult CNS can be traced back to a specific progenitor zone within a specific FMU, and the progeny of any FMU can be traced to their final positions with the help of selective labeling approaches. (7) Early outgrowing axons form bundles, which tend to pass close to the border zones of the radial units. By means of their molecularly diversely tuned growth cones, these extending axons decide how to behave at each boundary they encounter, sometimes even reorienting at right angles. Collectively these early axonal bundles form a checkerboard-like scaffold, which accentuates the molecular regionalization of the CNS and leads to the formation of topographically ordered synaptic fields. The book covers all of these aspects in detail, providing a morphologic model (blueprint) that highlights the natural coordinates of CNS structure resulting from the conserved molecularly controlled shaping phenomena within morphogenetic fields.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER
650		7	_aNeuropsiquiatría _9148157 _0comprobar BNE19931473544 _2embne
650		7	_aNeurología _0comprobar BNE19900967585 _2embne _9139040
700	1		_aPuelles, L. _0BNE19912801775 _917286
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-25693-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319256931
907			_a.b12943976 _b13-10-17 _c21-11-16
998			_am _a_alco _a_vill _b05-10-17 _cm _dz _ei _feng _ggw _h0
945			_aRC343.3 N548 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11588123 _z06-04-17
999			_c85119 _d85119 _x1