000			03821nam a22004215i 4500
001			84980
003			ES-MaUEC
005			20240611040140.0
007			cr nn 008mamaa
008			160318s2016 gw | s |||| 0|eng d
020			_a9783319238982
040			_aES-MaUEC
050		4	_aQR360 _b.Q37 2016 EB
082	0	4	_a616.9101
245	1	0	_aQuasispecies: From Theory to Experimental Systems _cedited by Esteban Domingo, Peter Schuster
250			_a1st ed.
264		1	_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XIV, 357 páginas) _b67 ilustraciones, 53 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aCurrent Topics in Microbiology and Immunology _x0070-217X _v392
505	0		_aWhat is a quasispecies?- Historical origins and current scope -- The nucleation of semantic information in prebiotic matter -- Evolution of RNA-based networks -- Quasispecies on fitness landscapes -- Mathematical models of quasispecies theory and exact results for the dynamics -- Theoretical Models of Generalized Quasispecies -- Theories of lethal mutagenesis: from error catastrophe to lethal defection -- Estimating fitness of viral quasispecies from next-generation sequencing data -- Getting to know viral evolutionary strategies: Towards the next generation of quasispecies models -- Cooperative Interaction within RNA Virus Mutant Spectra -- Arenavirus Quasispecies And Their Biological Implications -- Models of viral population dynamics -- Fidelity variants and RNA quasispecies -- Antiviral strategies based on lethal mutagenesis and error threshold.
520			_aThis volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology.�.
650		7	_aGenética humana _2embne _9140562
650		7	_aInmunología _2embne _9138330
700	1		_aDomingo, Esteban. _eeditor literario _975627 _0Local _0http://id.loc.gov/authorities/names/n87894624 _1http://viaf.org/viaf/51749428
700	1		_aSchuster, Peter. _eeditor literario _997608 _0Local _0http://id.loc.gov/authorities/names/n89632104 _1http://viaf.org/viaf/27081200
710	2		_aSpringerLink (Online service) _0Local _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-23898-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319238982
907			_a.b12942583 _b10-10-17 _c21-11-16
942			_2lcc _cLE
945			_aEBOOK EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11613099 _z30-06-17
988	0	0	_aEBOOK, EBSPRINGER, GOBI_sep2018
988			_aEbook_one2one
998			_aSI _a_alco _a_vill _b10/2018 _cm _dz _ef _feng _ggw _h0
999			_c84980 _d84980 _x1