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020			_a9783319234762
040			_aES-MaUEC
050		4	_aQP552.A87 _bA238 2016
082	0	4	_a571.64
245	1	0	_aABC Transporters - 40 Years on _cedited by Anthony M George
250			_a1st ed.
260			_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XIV, 376 páginas) _b50 ilustraciones, 6 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aABC Importers -- Inborn errors and potential correction of the cellular expression and localization of medically important ABC transporters -- Human ABC transporter ABCC11: Molecular mechanistic, pharmacological, and anthropological aspects -- Biology of mitochondrial ABCs and their contribution to pathology -- ABC transporters and multidrug resistance in fungi and yeast -- Structural and mechanistic insights into modulation of P-glycoprotein (ABCB1)function by tyrosine kinase inhibitors -- Techniques for the purification of ABC transporters -- HDAC inhibitors and MDR ABC transporters -- The role of polymorphisms in P-glycoprotein (ABCB1) on function -- Interaction of ABC transporters with drugs -- ABC insights from CFTR.
520	3		_aThis book provides new structural, biochemical, and clinical information on ABC transporters. The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within which chemotherapy failure is observed in about 50% of cases. Together with its complex pharmacology, and even a suspected role in Alzheimer�s disease, this ABC transporter still eludes a clinical solution to its multidrug resistance property. ABC transporters are integral membrane active proteins and they belong to one of the largest protein families across all species. Their myriad roles encompass the import or export of a diverse range of allocrites, including ion, nutrients, peptides, polysaccharides, lipids, and xenobiotics. They are of major medical importance with many members elaborating multidrug resistance in bacteria, fungi, yeast, parasites, and humans. Other ABC transporters are involved in a number of inherited diseases, including cystic fibrosis, macular degeneration, gout, and several other metabolic disorders.
650	0	4	_9495993 _aCiencias de la vida
650		7	_aResistencia a los medicamentos _0comprobar BNE19925042427 _2embne _9146972
700	1		_aGeorge, Anthony M. _eeditor literario _997518 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-23476-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319234762
907			_a.b1294211x _b10-10-17 _c21-11-16
942			_2lcc _cLE
945			_aQP552.A87 A238 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11586473 _z06-04-17
988			_aEBOOK, asignarmaterias , EBSPRINGER
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0