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001			84928
003			ES-MaUEC
005			20230207040447.0
007			cr nn 008mamaa
008			151218s2016 gw | s |||| 0|eng d
020			_a9783319234496
040			_aES-MaUEC
050		4	_aRC632.A43 _b2016 EB
082	0	4	_a616.2
245	1	0	_aAlpha-1 Antitrypsin : _bRole in Health and Disease _cedited by Adam Wanner, Robert A Sandhaus
250			_a1st ed.
260			_aCham _bSpringer International Publishing _bImprint _bHumana Press _c2016
300			_a1 recurso en línea (X, 173 p.) _b27 ilustraciones, 12 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aRespiratory Medicine _x2197-7372
505	0		_aAlpha-1- Antitrypsin and the Serpins -- Alpha-1 Antitrypsin: The protein -- Misfolding and Polymerisation of Alpha1-Antitrypsin � Conformational Pathology and Therapeutic Targeting -- Managing the Adaptive Proteostatic Landscape: Restoring Resilience in Alpha-1 Antitrypsin Deficiency -- United States Targeted Detection Program for Alpha-1 Antitrypsin Deficiency -- Lung Disease of Alpha-1 Antitrypsin Deficiency -- Alpha-1-Antitrypsin Deficiency: Role in Health and Disease -- Alpha-1 Antitrypsin as a Therapeutic Agents for Conditions not Associated with Alpha-1 Antitrypsin Deficiency -- The Alpha-1 Constellation of Voluntary Health Organizations as a Paradigm for Confronting Other Rare Diseases.
520			_aThis book offers a comprehensive overview of alpha-1 antitrypsin deficiency, an inherited condition that leads to lung disease in adults and liver disease in adults and children. While it is a rare condition, the mechanisms underlying its clinical manifestations have been largely clarified. Specific treatment, however, is�available only for the lung disease that arises from the condition, thus necessitating continued research into new and alternative therapeutic solutions. The book discusses the biology of alpha-1 antitrypsin, protein misfolding and polymerization, and diagnosis and treatment of alpha-1 antitrypsin deficiency and its associated diseases.� It concludes with a discussion of �alpha-1 antitrypsin therapy in diseases not associated with alpha-1 antitrypsin deficiency, and the role�of healthcare organizations in the rare disease space. Written for pulmonary clinicians and scientists, Alpha-1 Antitrypsin: Role in Health and Disease is a valuable resource that sheds light on this rare disease.�.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
650		7	_aMedicina _0comprobar BNE19900959047 _2embne _9405021
650	0	7	_aAparato respiratorio _0LocalX _2embne _9138569
650	1	7	_aSalud pública _0LocalX _2embne _9138408
650	0	7	_aSalud pública _0LocalX _2embne _9138408
700	1		_aWanner, Adam. _eeditor literario _997506 _0Local
700	1		_aSandhaus, Robert A. _eeditor literario _997507 _0Local
830		0	_aRespiratory Medicine _x2197-7372 _9133634
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-23449-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319234496
907			_a.b12942066 _b10-10-17 _c21-11-16
988			_aSpringer_Medicine_2016
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aRC632.A43 A474 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11586424 _z06-04-17
999			_c84928 _d84928 _x1