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008			160401s2016 gw a s 001 0 eng d
020			_a9783319222790
024	7		_a10.1007/978-3-319-22279-0
040			_aES-MaUEC
050		4	_aRC268.3 _b.S56 2016 EB
082	0	4	_a614.5999
100	1		_aSinkovics, Joseph G. _0local _997306 _0Local
245	1	0	_aRNA/DNA and Cancer _cby Joseph G Sinkovics
250			_a1st ed.
264		1	_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XI, 815 p.) _b75 ilustraciones, 52 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPreface. Introductions. I THE PRIMORDIAL RNA/DNA COMPLEX EVOLVING -- The Primordial Genes Are Conserved as Stem Cell Genes and Proto-Oncogenes -- The First Cells Ascend -- Eukaryotic Single Cells and the First Cell Communities Then and Now -- A Highly Effective Immune System Predating Adaptive Immunity -- Elements of Adaptive Immunity Self-Assemble -- The RNA/DNA Complex at Work -- YY Proteins -- Elusive Alleles -- The Long Trajectory of the IGF-like Receptor and Its Ligands -- Primordial Fused Genes Become Oncogenes and Encode Oncoproteins -- Performance in the Laboratory -- Inbuilt Errors not yet Corrected -- Errors or Inherent Attributes for the Sustenance of Unicellular Life -- Viral Genomic Insertions in the Host Cell{u2019}s Genome -- Viral and Cellular Proteins Interact -- Light Cast to Broken DNA, Its Repair, and Consequences -- Undisciplined Introns -- Elementary Epigenomics -- RNA/DNA: Bioengineers Supreme -- II THE ONCOGENOME -- Seamless Unity of the Nucleus and Cytoplasm: the Membranes Are Permeable -- Endogenously Initiated Immortalization is Welcome. Enforced Carcinogenesis by Exogenous Alien Initiator Is Resisted -- A Condensed Compendium -- zMalignant Transformationy -- III THE HUMAN CEREBRAL CORTICAL DNA AGAINST CANCER CELL DNA -- Will the Human Cerebral Cortex Subdue the Oncogenome?- In Self-Defense, the Cancer Cell Reactivates Its Primordial Genome Loaded with Proviruses in Order to Mobilize All Its Remaining Survival Pathways -- The Cancer Cell Viewed as a Unicellular Parasite (an Amoeba) -- Astute Observers Withstand Derision -- zMaking Cancer Historyy at M.D. Anderson Hospital -- SUMMARY -- Appendix 1 -- Appendix 2 -- Index.
520	3		_aIn this book, the author Joseph G. Sinkovics liberally shares his views on the cancer cell which he has been observing in vivo and in vitro, over a life time. Readers will learn how, as an inherent faculty of the RNA/DNA complex, the primordial cell survival pathways are endogenously reactivated in an amplified or constitutive manner in the multicellular host, and are either masquerading as self-elements or as placentas, to which the multicellular host is evolutionarily trained to extend full support. The host obliges. The author explains that there is no such evidence that zmalignantly transformedy human cells survive in nature. However, when cared for in the laboratory, these cells live and replicate as immortalized cultures. These cells retain their vitality upon storage in liquid nitrogen. One can only imagine an astrophysical environment in which such cells could survive; perhaps, first their seemingly humble exosomes would populate that environment. Immortal cell populations so created may survive as individuals, or may even re-organize themselves into multicellular colonies, as representatives of life for the duration of the Universe. This thought-provoking book is the work of a disciplined investigator and clinician with an impeccable reputation, and he enters a territory that very few if any before him have approached from the same angles. It will appeal to researchers with an interest in cell survival pathways and those researching cancer cells.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER
650		7	_aCáncer _xAspectos inmunológicos _9195595 _0comprobar BNE19923507443 _2embne
650		7	_aARN _0comprobar BNE19913480892 _2embne _9144940
650		7	_aInmunología _0comprobar BNE19900958507 _2embne _9138330
650		7	_aADN _0comprobar BNE19900989837 _2embne _9140806
650		7	_aOncología _0comprobar BNE19900969554 _2embne _9139207
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-22279-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319222790
907			_a.b12940999 _b04-11-17 _c21-11-16
998			_am _a_alco _a_vill _b04-11-17 _cm _dz _eo _feng _ggw _h0
945			_aRC268.3 .S56 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11585407 _z06-04-17
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