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008			160329s2016 gw | s |||| 0|eng d
020			_a9783319067131
040			_aES-MaUEC
050		4	_aRC641.7.S5 _b2016 EB
082	0	4	_a616.15
245	1	0	_aSickle Cell Anemia : _bFrom Basic Science to Clinical Practice _cedited by Fernando Ferreira Costa, Nicola Conran
260			_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XV, 435 páginas) _b64 ilustraciones, 50 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aChapter 1 Hemoglobin: Structure, Synthesis and Oxygen Transport -- Chapter 2 Sickle cell Anemia: History and Epidemiology -- Chapter 3 Overview of Sickle Cell Anemia Pathophysiology -- Chapter 4 Red Blood Cells and the Vaso-occlusive Process -- Chapter 5 Leukocytes in the vaso-occlusive process -- Chapter 6 Hypercoagulability and Sickle Cell Disease -- Chapter 7 Cardiovascular Adaptations to Anemia and the Role of Vascular Endothelium in Sickle Cell Disease Pathophysiology -- Chapter 8 Inflammation and Sickle Cell Anemia -- Chapter 9 Clinical Manifestations of Sickle Cell Anemia: Infants and Children -- Chapter 10 Treatment of Childhood Sickle Cell Disease -- Chapter 11 Priapism in Sickle Cell Disease: New aspects of pathophysiology -- Chapter 12 Clinical Manifestations and Treatment of Adult Sickle Cell -- Chapter 13 Hemoglobin SÝ Thalassemia, SC Disease and SD Disease: Clinical and Laboratorial Aspects -- Chapter 14 Sickle Cell Disease in Africa and the Arabian Peninsula: Current Management and Challenges -- Chapter 15 Genetic Factors modifying sickle cell disease severity -- Chapter 16 Future Perspectives for the Treatment of Sickle Cell.
520	3		_aAlthough sickle cell anemia was the first molecular disease to be identified, its complex and fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of symptoms associated with the disease. Our knowledge regarding sickle cell disease mechanisms, while still not complete, has broadened considerably over the last decades. Sickle Cell Anemia: From Basic Science to Clinical Practice aims to provide an update on our current understanding of the disease�s pathophysiology and use this information as a basis to discuss its manifestations in childhood and adulthood. Current therapies and prospects for the development of new approaches for the management of the disease are also covered.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
650		7	_aMedicina _0comprobar BNE19900959047 _2embne _9405021
650		7	_aMedicina interna _0comprobar BNE19900959227 _2embne _9138387
700	1		_aCosta, Fernando Ferreira _eeditor literario _0Local _996771
700	1		_aConran, Nicola _eeditor literario _0Local _996772
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-06713-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319067131
907			_a.b12938063 _b10-10-17 _c21-11-16
988			_aSpringer_Medicine_2016
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aRC641.7.S5 S535 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11582686 _z06-04-17
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