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008			160411s2016 gw | s |||| 0|eng d
020			_a9783319015743
040			_aES-MaUEC
050		4	_aRC662.18 _bT444 2016
245	1	4	_aThe Genetics of Type 2 Diabetes and Related Traits : _bBiology, Physiology and Translation _cedited by Jose C Florez
260			_aCham _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XI, 576 páginas) _b53 ilustraciones, 13 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPart I Genetic Discovery -- Part II Interpretation and Data Integration -- Part III From Association to Function -- Part IV Clinical Translation.�.
520	3		_aThis book presents the state of the art of type 2 diabetes genetics, from the process of genetic discovery to its interpretation and clinical application, and illustrates a model for other complex human phenotypes. The first section explores genome-wide association studies, the extension of this method to less accessible phenotypes and the arrival of next-generation sequencing. A further section goes beyond genetics to illustrate how other data sources can help interpret genetic data, such as leveraging population diversity, the correlation of genetic associations with physiological measurements, gene expression modulation, environmental factors and our microbial commensals. The third section describes advances in elucidating the complex path from association to function using in-depth sequencing and functional studies of the cellular and molecular effects of genes in the loci identified by genetics. The final section links our current understanding with clinically relevant questions, such as prediction, interactions with drugs or nutrients, and disease prevention, and paints a realistic but hopeful vision of the future. <.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988	0	0	_aEBOOK, EBSPRINGER, asignarmaterias_11febrero
650		7	_aMedicina _0comprobar BNE19900959047 _2embne _9405021
650		7	_aGenética humana _0comprobar BNE19900986777 _2embne _9140562
650		7	_aFisiología humana _0comprobar BNE19900979803 _2embne _9140024
700	1		_aFlorez, Jose C. _eeditor literario _996746 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-01574-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319015743
907			_a.b12937903 _b10-10-17 _c21-11-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h4
945			_aRC662.18 T444 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11582558 _z06-04-17
999			_c84512 _d84512 _x1