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020			_a9781493963836
040			_aES-MaUEC _bspa
050		4	_aQH603.C43 _bD57 2016 EB
082	0	4	_a614.5999
245	1	0	_aDiscoidin Domain Receptors in Health and Disease _cedited by Rafael Fridman, Paul H Huang
264		1	_aNew York, NY _bSpringer New York _c2016
300			_a1 recurso en línea (XIV, 355 páginas) _b82 ilustraciones, 55 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPart I: Discoidin Domain Receptor biology and roles in physiology -- DDRs: Binding properties, cell adhesion and modulation of integrin function -- DDRs and collagen fibrillogenesis -- DDR Structural Biology -- DDR Mouse models -- DDR in Invertebrates -- Part II: Discoidin Domain Receptors in Cancer -- Discoidin Domain Receptors and Disease -- Discoidin Domain Receptors in Normal Mammary Development and Breast Cancer Progression -- Discoidin Domain Receptors in Lung Cancer -- DDRs in healthy and cancerous reproductive systems -- Small Molecule Inhibitors of Discoidin Domain Receptors -- Discoidin Domain Receptor Signaling Networks -- Discoidin Domain Receptor Signaling and Pharmacological Inhibitors -- Functions of DDR1 in epithelial cell differentiation -- Part III: Discoidin Domain Receptors in other pathologies -- Discoidin Domain Receptor 2 in Development of Osteoarthritis -- DDR1 in Renal Function and Disease -- Discoidin Domain Receptors in Liver Fibrosis -- The role of DDRs in Atherosclerosis -- Discoidin Domain Receptors in Cardiac Development.
520			_aThe interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. A failure to establish these normal interactions and to interpret the cues emanating from the ECM is one of the major causes in abnormal development and the pathogenesis of multiple diseases. To recognize and act upon the biophysical signals that are generated by the cross talk between cells and ECM, the cells developed specific receptors, among them a unique set of receptor tyrosine kinases (RTKs), known as the Discoidin Domain Receptors (DDRs). The DDRs are the only RTKs that specifically bind to and are activated by collagen, a major protein component of the ECM. Hence, the DDRs are part of the signaling networks that translate information from the ECM, and thus they are key regulators of cell-matrix interactions. Under physiological conditions, DDRs control cell and tissue homeostasis by acting on collagen sensors; transducing signals that regulate cell polarity, tissue morphogenesis, cell differentiation, and collagen deposition. DDRs play a key role in diseases that are characterized by dysfunction of the stromal component, which lead to abnormal collagen deposition and the resulting fibrotic response that disrupt normal organ function in disease of the cardiovascular system, lungs and kidneys, just to mention a few. In cancer, DDRs are hijacked by tumor and stromal cells to disrupt normal cell-collagen communication and initiate pro-oncogenic programs. Importantly, several cancer types exhibit DDR mutations, which are thought to alter receptor function, and contribute to cancer progression. Therefore, the strong causative association between altered RTK function and disease it is been translated today in the development of specific tyrosine kinase inhibitors targeting DDRs for various disease conditions. In spite of the accumulating evidence highlighting the importance of DDRs in health and diseases, there is still much to learn about these unique RTKs, as of today there is a lack in the medical literature of a book dedicated solely to DDRs. This is the first comprehensive volume dedicated to DDRs, which will fill a gap in the field and serve those interested in the scientific community to learn more about these important receptors in health and disease.
650		7	_aCitología _2embne _9139477
700	1		_aFridman, Rafael _eeditor literario _0Local _0http://id.loc.gov/authorities/names/n2016191130 _1http://viaf.org/viaf/1037148451572415970002 _996709
700	1		_aHuang, Paul H. _eeditor literario _996710 _0Local _0http://id.loc.gov/authorities/names/n2016191131 _1http://viaf.org/viaf/121148449651715690910
710	2		_aSpringerLink (Online service) _0Local _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4939-6383-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781493963836
907			_a.b1293771x _b10-10-17 _c21-11-16
942			_2lcc _cLE
945			_aEBOOK EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11612745 _z30-06-17
988	0	0	_aEBOOK, EBSPRINGER, GOBI_sep2018
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998			_aSI _a_alco _a_vill _b10/2018 _cm _dz _ek _feng _gxxu _h0
999			_c84493 _d84493 _x1