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003			ES-MaUEC
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007			cr nn 008mamaa
008			160810s2016 xxu| s |||| 0|eng d
020			_a9781493956173
040			_aES-MaUEC
082	0	4	_a612
050		4	_aQH513 _b.M654 2016 EB
245	1	0	_aMolecular and Cellular Mechanobiology _cedited by Shu Chien, Adam J Engler, Peter Yingxiao Wang
264		1	_aNew York, NY _bSpringer New York _c2016
300			_a1 recurso en línea (XIII, 302 páginas) _b58 ilustraciones, 57 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aPhysiology in Health and Disease
505	0		_aPart 1. Mechanosensors -- The Primary Cilium as a Strain Amplifying Microdomain for Mechanotransduction at the Cell Membrane -- Vascular Endothelial Mechanosensors in Response to Fluid Shear Stress -- Cadherins in Mechanotransduction -- Perspectives of FRET Imaging to study Epigenetics and Mechanobiology in the Nucleus -- Part 2. Transducers -- Emerging Roles of YAP/TAZ in Mechanobiology -- Role of Rho GTPases in Mechanobiology -- Illuminating Cell Adhesion: Modern Microscopy Approaches to Study Integrin-Based Focal Adhesions -- Part 3. Epigenetic and Genetic Regulations in the Nucleus -- Mechanotransduction to Epigenetic Remodeling -- The Nuclear Lamina: From Mechano-Sensing in Differentiation to Cancer Cell Migration -- Role of Cell Geometry on Nuclear Mechanics, Chromosome Reorganization, and Gene Expression -- Part 4. Applications -- Mechanobiological Control of Cell Fate for Applications in Cardiovascular Regenerative Medicine -- Heart Valve Mechanobiology in Development and Disease -- Molecular and Cellular Mechanobiology of Cancer.
520			_aThis book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease. A comprehensive understanding of the roles of physicochemical microenvironment and intracellular responses in determining cellular function in health and disease will also be discussed.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988	0	0	_aEBOOK, EBSPRINGER
650		7	_aBiomecánica _0comprobar BNE19902550147 _2embne _9143819
700	1		_aChien, Shu _eeditor literario _0Local _996706
700	1		_aEngler, Adam J. _eeditor literario _996707 _0Local
700	1		_aWang, Peter Yingxiao. _eeditor literario _996708 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4939-5617-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781493956173
907			_a.b12937708 _b10-10-17 _c21-11-16
945			_aEBOOK EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11612733 _z30-06-17
998			_aSI _b07/2018 _cm _dz _ea _feng _gxxu _h0
999			_c84492 _d84492 _x1