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003			ES-MaUEC
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007			cr nn 008mamaa
008			160303s2016 xxu| s |||| 0|eng d
020			_a9781493935093
040			_aES-MaUEC _bspa
050		4	_aQH442 _b.G46 2016 EB
082	0	4	_a599.935
082	0	4	_a611.01816
245	1	0	_aGenome Editing : _bThe Next Step in Gene Therapy _cedited by Toni Cathomen, Matthew Hirsch, Matthew Porteus
250			_a1st ed.
264		1	_aNew York, NY _bSpringer New York _c2016
300			_a1 recurso en línea (XVI, 263 páginas) _b48 ilustraciones, 5 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598
505	0		_a1. Gene Editing: Double-Strand Break Induced Gene Targeting and Mutagenesis 20 Years Later -- 2. The Development and Use of Zinc-Finger Nucleases -- 3.The Use and Development of TAL Effector Nucleases -- 4. Genome Editing for Neuromuscular Diseases -- 5. Phage Integrases for Genome Editing -- 6. Precise Genome Modification Using Triplex Forming Oligonucleotides and Peptide Nucleic Acids -- 7. Genome Editing by Aptamer-Guided Gene Targeting -- 8. Stimulation of AAV Gene Editing via DSB Repair -- 9. Engineered Nucleases and Trinucleotide Repeat Diseases -- 10. Using Engineered Nucleases to Create HIV-Resistant Cells -- 11. Strategies to Determine Off-Target Effects of Engineered Nucleases.
520			_aThis comprehensive volume explores human genetic engineering its pre-clinical and clinical applications, current developments, and as treatment for hereditary diseases. It presents and evaluates the most recent advances in the understanding of mammalian host DNA repair mechanisms, such as double-strand break induced gene targeting and mutagenesis, the development of zinc-finger nucleases, genome editing for neuromuscular diseases, phase integrases, triplex forming oligonucleotides and peptide nucleic acids, aptamer-guided gene targeting, AAV gene editing via DSB repair, engineered nucleases and trinucleotide repeat diseases, and creation of HIV-resistant cells. The expertly authored chapters contextualize current developments within the history of genome editing while also discussing the current and potential safety concerns of this rapidly growing field. Genome Editing: The Next Step in Gene Therapy, the latest volume in the American Society of Gene and Cell Therapy series, deftly illuminates the potential of genetic engineering technology to eradicate today�s deadliest and most prolific diseases. It is ideal reading for clinicians and researchers in genetics and immunology. .
650		7	_aIngeniería genética _2embne _9141520
650		7	_aGenética humana _2embne _9140562
700	1		_aCathomen, Toni _eeditor literario _0Local _0http://id.loc.gov/authorities/names/nb2016008032 _1http://viaf.org/viaf/280823984 _996669
700	1		_aHirsch, Matthew _eeditor literario _0Local _0http://id.loc.gov/authorities/names/nb2016008033 _1http://viaf.org/viaf/86146284323315331223 _996670
700	1		_aPorteus, Matthew. _eeditor literario _996671 _0Local _1http://viaf.org/viaf/26146575006438152575
710	2		_aSpringerLink (Online service) _0Local _0http://id.loc.gov/authorities/names/no2005046756 _1http://viaf.org/viaf/148105729 _9106996
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4939-3509-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781493935093
907			_a.b12937514 _b10-10-17 _c21-11-16
942			_2lcc _cLE
945			_aEBOOK EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11612617 _z30-06-17
988	0	0	_aEBOOK, EBSPRINGER, GOBI_sep2018
988			_aEbook_one2one
998			_aSI _a_alco _a_vill _b10/2018 _cm _dz _ek _feng _gxxu _h0
999			_c84473 _d84473 _x1