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008			160520s2016 xxu| s |||| 0|eng d
020			_a9781493932771
040			_aES-MaUEC
050		4	_aRC1075 _b.E344 2016
082	0	4	_a616.079
245	1	0	_aEffect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial Cells : _bNovel Insights into Disease Mechanisms _cedited by Cheryl A Nickerson, Neal R Pellis, C Mark Ott
250			_a1st ed.
260			_aNew York, NY _bSpringer New York _c2016
300			_a1 recurso en línea (XVIII, 301 p.) _b66 ilustraciones, 45 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aForeword -- Chronology of Key Spaceflight and Spaceflight Analogue Culture Experiments using Human and Microbial Cells -- Part I. The Principles and Translational Impact of Space Life Sciences Research -- Overview and Translational Impact of Space Cell Biology Research.-�Principles of Analogue and True Microgravity Bioreactors for Tissue Engineering.-�Immune Dysfunction in Spaceflight:�An Integrative View.-�Part II. Human and Cellular Investigations -- Biomedical Advances in Three Dimensions: An Overview of Human Cellular Studies in Space and Spaceflight Analogues.-�Outpacing Infectious Disease: �Mimicking�the Host-Pathogen Microenvironment.-�Use of in vitro Cell Culture Models to Understand the Cellular and Molecular Basis of Immune Dysfunction during Spaceflight.-�Using a Spaceflight Three-Dimensional Microenvironment to Probe Cancer-Stromal Interactions.-�Skeletal Muscle Tissue Culture Under Spaceflight Conditions.-�Microgravity and Microgravity Analogue Studies of Cartilage and Cardiac Tissue Engineering.-�Part III. Microbial Investigations -- Microbial Investigations: Overview.-�Using Spaceflight and Spaceflight-Analogue Culture for Novel Mechanistic Insight into Salmonella Pathogenesis.-�Response of Pseudomonas aeruginosa to Spaceflight and Spaceflight Analogue Culture: Implications for Astronaut Health and the Clinic.-�Cellular responses of Escherichia coli to Microgravity and Microgravity Analogue Culture.-�Spaceflight and Spaceflight Analogue-Induced Responses in Gram Positive Bacteria. �.
520			_aMany breakthroughs in biological research and translational healthcare advancements have been achieved by studying the response of biological systems to extreme environments. The spaceflight platform provides a unique environment where researchers can explore fundamental questions into cellular and molecular response mechanisms to unveil novel insight into human health and disease. Since the physical force of gravity has shaped the architecture of all biological systems on our planet, spaceflight provides the opportunity to see life in a new adaptational mode - in response to reduced gravity. This enables investigations into the effects of the microgravity environment and associated changes in mechanical forces on mammalian cells/tissues and microbial pathogens, to bring novel insight into disease mechanisms, which are not discernable using conventional experimental approaches. Research using spaceflight platforms represents a paradigm shift in how we observe life processes and is on the leading edge of research discoveries into cellular and molecular mechanisms of health and disease. By incorporating the views of leading authors, this book highlights landmark discoveries and advances in mammalian cellular and microbiology research in both true spaceflight and ground-based spaceflight analogue environments for scientists and students alike who are interested in the influence of physical forces on mammalian and microbial cells, how this impacts transition between normal homeostasis and disease, and basic mechanisms of adaptation to low gravity environments. To provide a thorough understanding of this research, this book covers a range of topics including: (i) description the physical forces interacting with cells in microgravity and microgravity analogue environments, (ii) how alterations in these cellular forces impact human physiology, specifically immune function, (iii) use of these environments to develop organotypic three-dimensional (3-D) tissue culture models as predictive human surrogates for organogenesis and disease research, and (iv) microbial pathogen responses to culture in these environments, focusing on infectious disease Collectively, this information reflects a critical step in preparation for long-duration human space exploration, advances our knowledge of basic biological processes and mechanisms important to understand normal function and disease, and may lead to new strategies for treatment and prevention.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988	0	0	_aEBOOK, EBSPRINGER
650		7	_aMedicina _0comprobar BNE19900959047 _2embne _9405021
650		7	_aInmunología _0comprobar BNE19900958507 _2embne _9138330
650		7	_9405049 _aMicrobiología médica _0comprobar BNE19900963008 _2embne
700	1		_aNickerson, Cheryl A. _eeditor literario _984170 _0Local
700	1		_aPellis, Neal R. _eeditor literario _996640 _0Local
700	1		_aOtt, C. Mark. _eeditor literario _996641 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4939-3277-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781493932771
907			_a.b12937319 _b10-10-17 _c21-11-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gxxu _h0
945			_aRC1075 .E344 2016 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11582145 _z06-04-17
999			_c84453 _d84453 _x1