| 000 | 02452nam a22003735i 4500 | ||
|---|---|---|---|
| 001 | 82462 | ||
| 003 | ES-MaUEC | ||
| 005 | 20230202103428.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 150916s2015 gw | s |||| 0|eng d | ||
| 020 | _a9783319202914 | ||
| 040 | _aES-MaUEC | ||
| 050 | 4 |
_aRC268.4 _b2015 EB |
|
| 082 | 0 | 4 | _a616.994 |
| 245 | 0 | 0 |
_aChromosomal Instability in Cancer Cells _cedited by B Michael Ghadimi, Thomas Ried |
| 250 | _a1st ed. | ||
| 260 |
_aCham, Switzerland _bSpringer _c2015 |
||
| 300 | _a1 recurso en línea (VII, 224 p.) 39 il. col. | ||
| 336 |
_aTexto (visual) _btxt _2rdacontent |
||
| 337 |
_aelectrónico _bc _2rdamedia |
||
| 338 |
_arecurso electrónico _bcr _2rdacarrier |
||
| 338 |
_aonline resource _bcr _2rdacarrier |
||
| 490 | 1 |
_aRecent Results in Cancer Research _x0080-0015 _v200 |
|
| 520 | _aThis issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification. | ||
| 942 |
_2lcc _cLE |
||
| 650 | 7 |
_aCáncer _xAspectos genéticos _9273952 _0comprobar BNE19990911214 _2embne |
|
| 700 | 1 |
_aGhadimi, B. Michael _eeditor literario _995419 _0Local |
|
| 700 | 1 |
_aRied, Thomas _eeditor literario _995420 _0Local |
|
| 856 | 4 | 0 |
_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-20291-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid) |
| 907 |
_a.b12911021 _b10-10-17 _c10-02-16 |
||
| 988 | _aSpringer_Medicine_2015 | ||
| 998 |
_am _a_alco _a_vill _b14-12-16 _cm _dz _ea _feng _ggw _h0 |
||
| 945 |
_aRC268.4 C476 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11578701 _z06-04-17 |
||
| 999 |
_c82462 _d82462 _x1 |
||