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007			cr nn 008mamaa
008			150615s2015 gw | s |||| 0|eng d
020			_a9783319173504
024	7		_a10.1007/978-3-319-17350-4 _2doi
050		4	_aQP99.3.A65 _b2015 EB
245	1	0	_aApolipoprotein Mimetics in the Management of Human Disease _cedited by G.M. Anantharamaiah, Dennis Goldberg.
260			_aCham _bSpringer International Publishing _bImprint: Adis _c2015.
300			_a1 recurso en línea (XXI, 182 páginas) _b42 ilustraciones, 22 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_a1. HDL and the Amphipathic Helix -- 2. ApoA-I mimetic peptides: A review of the present status -- 3. Apolipoprotein Mimetic Peptides for Stimulating Cholesterol Efflux -- 4. ApoA-I Mimetic Peptides and Diabetes -- 5. Apolipoprotein A-I mimetic peptides in Mouse Models of Cancer -- 6. Effects of ApoA-I mimetic peptide L-4F in LPS-mediated inflammation -- 7. Apolipoprotein mimetics in the amelioration of respiratory inflammation -- 8. Regulation of Macrophage Polarity by HDL, Apolipoproteins And Apolipoprotein Mimetic Peptides -- 9. Apolipoprotein E & Atherosclerosis: Beyond Lipid Effects -- 10. Apolipoprotein E mimetic peptides â€èolesterol dependent and independent properties -- 11. Apolipoprotein-E and Mimetics as Targets and Therapeutics for Alzheimerâ€{u3804}isease.
520	3		_aThis comprehensive book provides not only the stages in the development of this unique and specialized field but also updates on the current state of research and development of apolipoprotein mimetics as therapeutic modalities for various lipid-mediated disorders. The book consists of 11 chapters all written by leading scientists from well-reputed laboratories in the USA. After an introduction by Dr. Godfrey Getz, Professor of Medicine at the University of Chicago and the Associate Editor of the Journal Lipid Research, the book presents a narration of how a theory can lead to the discovery of treatment modalities to several devastating diseases such as diabetes, Alzheimerâ€{u3824}isease, arthritis; asthma; atherosclerosis, chronic rejection of transplanted hearts and cancer. Present therapies for most of these diseases are not adequate. Using the models of two long anti-atherogenic and anti-inflammatory proteins (apolipoprotein A-I and apolipoprotein E with 243 and 299 amino acids, respectively) short mimetic peptides of 18 to 28 amino acid residues in length, which can be produced either synthetically or genetically in edible fruits and vegetables, have been shown to exert profound biological effects in a large number of animal models of diseases. The book also presents novel ideas, highly unexpected mechanisms of action in animal models and even in initial clinical studies in humans, which can lead to additional improvements in basic and clinical research in biological science. All the chapters are written by experts in their respective fields who have contributed immensely to the literature. This is the first compendium of this growing field presented in the form of a book.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
650		7	_aBioquímica clínica _2embne _9149316
650	2	7	_aBioquímica clínica _2embne _9149316
700	1		_aAnantharamaiah, G. M. _eeditor literario _0Local _995278
700	1		_aGoldberg, Dennis _eeditor literario _995279 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-17350-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12910211 _b10-10-17 _c10-02-16
988			_aSpringer_Medicine_2015
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aQP99.3.A65 A665 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11577897 _z06-04-17
999			_c82381 _d82381 _x1