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710	2		_aSpringerLink (Online service) _0Local _9106996
988			_aSpringer_Medicine_2015
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008			150624s2015 gw | s |||| 0|eng d
020			_a9783319153445
024	7		_a10.1007/978-3-319-15344-5 _2doi
040			_aES-MaUEC
050		4	_aRM301.3.G45 _b2015 EB
245	1	0	_aPreventive and Predictive Genetics: Towards Personalised Medicine _cedited by Godfrey Grech, Iris Grossman.
260			_aCham, Switzerland _bSpringer _c2015
300			_a1 recurso en línea (XX, 378 páginas) _b18 ilustraciones, 8 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aAdvances in Predictive, Preventive and Personalised Medicine _x2211-3495 _v9
505	0		_aIntroduction -- Preventive and Predictive Genetics: A perspective -- Roadmap to Drug Development Enabled by Pharmacogenetics -- Preventative and Predictive Genetics: Towards Personalised Medicine -- Pharmacokinetics and Pharmacogenetics: bringing the magic bullet closer to reality -- Pharmacogenetics of Adverse Drug Reactions -- Pharmacogenomics for haemoglobinopathies therapeutics -- Pharmacogenetics of Neurodegenerative Disorders -- Pharmacogenetics of asthma -- Pharmacogenetics and antineoplastic therapies -- Pharmacogenetics of coumarin anticoagulant therapy -- Implementation of Genomic Medicine: tools and challenges -- Ethical Considerations in the Genomic Era -- Index.
520	3		_aTraditionally, medical research comprised of the identification of the pathological causes of a disease, its epidemiology and empirical investigation of treatment response. Intensive genetic research, marked by the completion of the human genome project in 2003, heralded a new era in medical research. While epidemiology and gross pathology are still mainstay useful tools, genetics and genomics have gradually been shown to increase the resolution of drug response research, showing great potential in also informing and identifying the role of genes and their encoded products in the pathophysiology of diseases. This information is already being applied in the prevention of illness, effective early diagnosis, better risk assessment (prognosis), as well as targeted effective and safe treatment allocation (prediction and monitoring). Genetic testing and genomics support personalised medicine by translating genome-based knowledge into clinical practice, offering enhanced benefit for patients and health-care systems at large. Current routine practice for diagnosing and treating patients is conducted by correlating parameters such as age, gender and weight with risks and expected treatment outcomes. In the new era of personalised medicine the healthcare provider is equipped with improved ability to prevent, diagnose, treat and predict outcomes on the basis of complex information sources, including genetic and genomic data. Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions.
650		7	_aResistencia a los medicamentos _2embne _9146972
650		7	_aBiología molecular _0 _2embne _9139103
650		7	_aGenética humana _0 _2embne _9140562
700	1		_aGrech, Godfrey _eeditor literario _995164 _0Local
700	1		_aGrossman, Iris _eeditor literario _995165 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-15344-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12909579 _b10-10-17 _c10-02-16
942			_2lcc _cLE
945			_aRM301.3.G45 P748 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11577253 _z06-04-17
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