000			04176nam a22004095i 4500
988			_aSpringer_Medicine_2015
999			_c82314 _d82314 _x1
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003			ES-MaUEC
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007			cr nn 008mamaa
008			150323s2015 gw | s |||| 0|eng d
020			_a9783319151083
024	7		_a10.1007/978-3-319-15108-3 _2doi
040			_aES-MaUEC _bspa
050		4	_aRC620.5 _b2015 EB
245	1	0	_aAlkaptonuria and Ochronosis _cedited by Jozef Rovenský, Tibor Urbánek, Boldišová Oľga, James A. Gallagher
260			_aCham, Switzerland _bSpringer _c2015
300			_a1 recurso en línea (VIII, 156 páginas) _b56 ilustraciones, 26 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aIntroduction -- Alkaptonuria and Ochronosis -- History -- Metabolism of Aromatic Amino Acids -- Tyrosine Metabolism Disorders -- Detection of Homogentisic Acid in Plasma and Urine -- Alkaptonuria Genetics -- Experimental Alkaptonuria in Animals -- Experimental Models of Alkaptonuria and Ochronosis -- Ochronotic Arthropathy -- Clinical Manifestation of Ochronotic Arthropathy in the Spine -- Analysis of X-Ray Symptomatology of Ochronotic Arthropathy in the Spine -- Clinical Manifestation of Ochronotic Arthropathy in the Peripheral Joints -- Clinical and Ultrasound Evaluation of Enthesopathy in Alkaptonuria in the Romani Community -- Analysis of X-Ray Symptomatology of Ochronotic Arthropathy in the Area of the Peripheral Joints -- Manifestations of Alkaptonuric Ochronosis in the Eye -- Symptoms of Alkaptonuria and Ochronosis in the Ear -- Manifestations of Alkaptonuria and Ochronosis in the Visceral Organs -- Manifestations of Alkaptonuria and Ochronosis in the Respiratory Tract -- Pathological Anatomy and Histology of Ochronosis -- Cellular and Molecular Patholgenesis of Ochronosis -- Picture of Synovial Effusion in Ochronosis -- Coincidence of Alkaptonuric Ochronosis with Other Diseases -- Differential Diagnosis of the Disease -- Sine Syndromes in Alkaptonuria -- History of Nitisinone (NTBC) -- Case Reports -- References.
520	3		_aThis book comprehensively describes alkaptonuria and ochronosis. Beginning with the history, genetics, pathophysiology and diagnostics of the disease, the authors subsequently present a detailed characterization of its clinical manifestation in the spine, peripheral joints, eyes, ears, visceral organs and respiratory tract, its pathological anatomy and histology, as well as differential diagnosis. This is complemented by the latest data on therapy and experimental models of alkaptonuria, and supported by several case reports. Numerous pictures and radiological images document the clinical symptoms, giving the reader a solid understanding of the disease. On the basis of the editorâ€{u3821}nd authorsâ€{u0BF7}n extensive observations, the book offers an analysis of protein metabolism and aromatic amino acids in the context of alkaptonuria. Written by international experts in the field, the book offers a valuable reference guide for healthcare professionals working in rheumatology, dermatology, pulmonology, otolaryngology and histopathology.
650		7	_aBiología molecular _2embne _9139103
650		7	_aAparato respiratorio _xEnfermedades _2embne _9405936
650		7	_aDermatología _2embne _9139590
700	1		_aRovenský Jozef _eeditor literario _988960 _0Local
700	1		_aUrbánek, Tibor _eeditor literario _995159 _0Local
700	1		_aBoldišová, Olga _eeditor literario _995160 _0Local
700	1		_aGallagher, James A. _eeditor literario _0Local _995161
710	2		_aSpringerLink (Online service) _0Local _9106996
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-15108-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12909543 _b10-10-17 _c10-02-16
942			_2lcc _cLE
945			_aRC620.5 A453 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11577228 _z06-04-17
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0