000			03577nam a22003735i 4500
001			82300
003			ES-MaUEC
005			20230207040405.0
007			cr nn 008mamaa
008			150319s2015 gw | s |||| 0|eng d
020			_a9783319146157
024	7		_a10.1007/978-3-319-14615-7 _2doi
050		4	_aRB148 _b2015 EB
245	1	0	_aFamilial Mediterranean Fever _cedited by Marco Gattorno.
260			_aCham, Switzerland _bSpringer _c2015
300			_a1 recurso en línea (VII, 162 páginas) _b17 ilustraciones, 12 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aRare Diseases of the Immune System _x2282-6505 _v3
505	0		_aPreface -- 1 Genetics.-Â{u2810}athogenesis.-Â{u3803}linical Picture in Childhood -- 4 Clinical Picture in Adulthood and Unusual Clinical Features.-Â{u5806}MF in Western Countries.-Â{u680C}ong Term Complications in FMF -- 7 Recent advances in quantitative assessment of FMF -- 8 How to Manage FMF Patients in Daily Practice -- 9 New Emerging Treatments.-Â{u3D62}ject Index.
520	3		_aThis book, written by very well known opinion leaders in the field, covers all aspects of familial Mediterranean fever, the most common monogenic autoinflammatory disease. The opening chapters explain the genetic basis of the disease and provide insights into the pathogenesis derived from recent experimental studies. A large part of the book is then devoted to a detailed description of the typical and atypical clinical presentations, the disease course, and potential complications in both pediatric and adult patients. Guidance is provided on the measurement of disease severity and the management of patients in daily practice. The advice regarding treatment is based on the best currently available evidence and attention is also paid to important emerging treatments. The book is part of Springerâ€{u3833}eries Rare Diseases of the Immune System, which presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. Monogenic autoinflammatory diseases are hereditary disorders that are caused by single-gene defects in innate immune regulatory pathways and are characterized by a clinical and biological inflammatory syndrome in which there is limited, if any, evidence of autoimmunity. Familial Mediterranean fever itself is due to a mutation in theÂ{uD146}FVÂ{u796E}e, which codes for the protein pyrin; it is characterized by periodic fever and episodes of painful inflammation in the abdomen, chest, and joints. Familial Mediterranean Fever will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with the disease.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
650		7	_aReumatología _2embne _9141883
650		7	_aGenética humana _2embne _9140562
650		7	_aInmunología _2embne _9138330
700	1		_aGattorno, Marco _eeditor literario _995138 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-14615-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12909403 _b10-10-17 _c10-02-16
988			_aSpringer_Medicine_2015
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aRB148 .F365 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11577083 _z06-04-17
999			_c82300 _d82300 _x1