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001			82244
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008			141211s2015 gw | s |||| 0|eng d
020			_a9783319126791
024	7		_a10.1007/978-3-319-12679-1 _2doi
050		4	_aRC523 _b2015 EB
100	1		_aBraak, Heiko _0Local _995045
245	1	0	_aNeuroanatomy and Pathology of Sporadic Alzheimer's Disease _cby Heiko Braak, Kelly Del Tredici.
260			_aCham, Switzerland _bSpringer _c2015
300			_a1 recurso en línea (XI, 162 páginas) _b48 ilustraciones, 44 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aAdvances in Anatomy, Embryology and Cell Biology _x0301-5556 _v215
505	0		_aPrologue -- General Morphology of Alzheimer-associated intraneuronal pathology -- Consistent and systematic changes in the distribution pattern of intraneuronal inclusions render staging possible -- Basic organization of involved structures -- Presymptomatic stages -- General morphology of Alzheimer-associated extracellular pathology -- Symptomatic stages -- The progression of cortical lesions mimics the pattern of myelination in reverse order -- Tauopathies -- CSF biomarkers and imaging techniques -- The staging hypothesis: assumptions, challenges, potential -- Technical considerations.Â{u2802}Â{uE000}
520	3		_aAs indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
650		0	_9140743 _aGeriatría _0
650		7	_aPatología _0 _2embne _9138489
650		7	_aNeurociencias _0 _2embne _9158907
700	1		_aDel Tredici, Kelly. _995046 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-12679-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12908848 _b10-10-17 _c10-02-16
988			_aSpringer_Medicine_2015
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aRC523 .B733 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11576522 _z06-04-17
999			_c82244 _d82244 _x1