000			03669nam a22003735i 4500
001			82236
003			ES-MaUEC
005			20230207040402.0
007			cr nn 008mamaa
008			150313s2015 gw | s |||| 0|eng d
020			_a9783319121086
024	7		_a10.1007/978-3-319-12108-6 _2doi
050		4	_aQP671.C83 _b2015 EB
245	1	0	_aCytochrome P450 : _bStructure, Mechanism, and Biochemistry _cedited by Paul R. Ortiz de Montellano.
250			_a4th ed. 2015.
260			_aCham, Switzerland _bSpringer _c2015
300			_a1 recurso en línea (X, 912 páginas) _b243 ilustraciones, 80 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aVolume 1 -- 1 Structures of Cytochrome P450 Enzymes -- 2 Electron Transfer Partners of Cytochrome P450 -- 3 Activation of Molecular Oxygen in Cytochromes P450 -- 4 Substrate Oxidation by Cytochrome P450 Enzymes -- 5 Inhibition of Cytochrome P450 Enzymes -- 6 Microbial Cytochromes P450 -- 7 P450s in Plants, Insects and their Fungal Pathogens -- 8 P450 Biotechnology -- Volume 2 -- 9 Human Cytochrome P450 Enzymes -- 10 Nuclear Receptor-Mediated Regulation of Cytochrome P450 Genes -- 11 Hormonal Regulation of Liver Cytochrome P450 Enzymes -- 12 P450 Enzymes in Steroid Processing -- 13 P450 Enzymes in Lipid Oxidation.
520	3		_aThis authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cytochrome P450 enzymes, with sufficient coverage of earlier work to make each chapter a comprehensive review of the field. Thirteen chapters are divided into two detailed volumes, the first covering the fundamentals of cytochrome P450 biochemistry, as well as the microbial, plant, and insect systems, and the second exclusively focusing on mammalian systems. Â{u05AF}lume 1 begins with an exploration of the biophysics and mechanistic enzymology of cytochrome P450 enzymes, with a discussion of the structures of P450 enzymes and their electron donor partners, the mechanisms of oxygen activation and substrate oxidation, and the approaches and nature of cytochrome P450 inhibition. Two more chapters discuss the nature and roles of cytochrome P450 enzymes in microbes, plants and insects, and an eighth chapter is a survey of the potential utility of P450 enzymes in biotechnology. The first chapter of Volume 2 examines the roles of P450 enzymes in mammals, mainly humans. Four further chapters then deal with the genetic and hormonal regulation of P450 enzymes and their specific roles in the processing of sterols and lipids. Cytochrome P450: Structure, Mechanism, and Biochemistry is a key resource for scientists, professors, and students interested in fields as diverse as biochemistry, chemistry, biophysics, molecular biology, pharmacology and toxicology.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
650		7	_aFarmacia _0 _2embne _9137891
650	1	7	_aFarmacia _0 _2embne _9137891
650		7	_aFarmacología _0 _2embne _9137893
700	1		_aOrtiz de Montellano, Paul R _eeditor literario _995033 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-12108-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12908769 _b10-10-17 _c10-02-16
988			_aSpringer_Medicine_2015
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aQP671.C83 C986 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11576443 _z06-04-17
999			_c82236 _d82236 _x1