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020 _a9789401794213
024 7 _a10.1007/978-94-017-9421-3
_2doi
040 _aES-MaUEC
050 4 _aRC268.5
_b.S77 2015 EB
082 0 4 _a614.5999
245 1 0 _aStress Response Pathways in Cancer :
_bFrom Molecular Targets to Novel Therapeutics
_cedited by Georg T. Wondrak.
264 1 _aDordrecht, Netherlands
_bSpringer
_c2015
300 _a1 recurso en línea (XII, 446 páginas)
_b56 ilustraciones, 52 ilustraciones en color
336 _aTexto (visual)
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
505 0 _aPreface -- Introduction to cell stress responses in cancer: The big picture -- DNA repair dysregulation in cancer: From molecular mechanisms to synthetic-lethal opportunities -- Cell cycle checkpoint defects as anticancer targets: From molecular mechanisms to therapeutic opportunities -- p53 at the crossroads between stress response signaling and tumorigenesis: From molecular mechanisms to therapeutic opportunities -- Sirtuins as a double-edged sword in cancer: From molecular mechanisms to therapeutic opportunities -- MicroRNA regulated stress responses in cancer -- Senescence in oncogenesis: From molecular mechanisms to therapeutic opportunities -- Pro-senescence therapy for cancer: time for the clinic -- Integrating proteotoxic stress response pathways for induction of cell death in cancer cells: molecular mechanisms and opportunities -- The Hsp70 family of heat shock proteins in tumorigenesis: From molecular mechanisms to therapeutic opportunities -- The ubiquitin-proteasome system (UPS) as a cancer drug target: Emerging mechanisms and therapeutics -- Endoplasmatic reticulum stress in multiple myeloma: From molecular mechanisms to therapeutic opportunities -- Melanomagenic gene alterations viewed from a redox perspective: Molecular mechanisms and therapeutic opportunities -- Targeting hypoxic adaptations of cancer cells: Molecular mechanisms and therapeutic opportunities -- Targeting glycolytic adaptations of cancer cells: from molecular mechanisms to therapeutic opportunities -- At the crossroads between mitochondrial metabolite transport and apoptosis: VDAC1 as an emerging cancer drug target -- Inflammatory dysregulation and cancer: From molecular mechanisms to therapeutic opportunities -- Cell-nonautonomous ER stress-mediated dysregulation of immunity by cancer cells -- Index.
520 _aIt is now established that dysregulated cell stress response pathways play a critical role in tumorigenesis, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit cancer patients in the near future. Coauthored by recognized leaders in cancer research from five continents, this novel book provides a comprehensive perspective on cell stress response pathways and therapeutic opportunities. Focusing on the role of genotoxic, proteotoxic, oxidative, metabolic, and inflammatory stress in tumorigenesis, the book is essential reading for students, basic researchers, and biomedical health care professionals interested in cancer and therapeutic development.
650 7 _aCarcinogénesis
_2embne
_9146492
700 1 _aWondrak, Georg T
_eeditor literario
_994273
_0Local
_1http://viaf.org/viaf/313290337
710 2 _aSpringerLink (Online service)
_0Local
_0http://id.loc.gov/authorities/names/no2005046756
_1http://viaf.org/viaf/148105729
_9106996
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-94-017-9421-3
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907 _a.b12902846
_b10-10-17
_c18-01-16
942 _2lcc
_cLE
945 _aRC261-271 EB
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988 0 0 _aEBOOK, EBSPRINGER, GOBI_sep2018
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