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008			150930s2015 ne | s |||| 0|eng d
020			_a9789401774086
024	7		_a10.1007/978-94-017-7408-6 _2doi
050		4	_aQH546 _b.J569 2015
100	1		_aJin, Wenfei _0Local _994242
245	1	0	_aAdmixture Dynamics, Natural Selection and Diseases in Admixed Populations _cby Wenfei Jin.
250			_a1st ed. 2015.
260			_aDordrecht, Netherlands _bSpringer _c2015
300			_a1 recurso en línea (XIX, 114 páginas) _b32 ilustraciones, 29 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aSpringer Theses, Recognizing Outstanding Ph.D. Research _x2190-5053
505	0		_aIntroduction -- Distribution of length of ancestral chromosomal segments in admixed genomes -- Exploring population admixture dynamics via distribution of LACS -- Genome-wide search for signatures of natural selection in African Americans -- Complex selective forces shaping the genes underlying human diseases -- Materials and Methods.
520	3		_aIn this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shapinghuman susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER, asignarmaterias_11febrero
650		7	_aBiomatemáticas _2embne _9145951
650		7	_aGenética humana _2embne _9140562
650	2	7	_aGenética humana _2embne _9140562
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-94-017-7408-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12902676 _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gne _h0
945			_aQH546 .J569 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11572292 _z06-04-17
999			_c81677 _d81677 _x1