000			03864nam a22003855i 4500
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001			81656
003			ES-MaUEC
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007			cr nn 008mamaa
008			150728s2015 ne | s |||| 0|eng d
020			_a9789401771979
024	7		_a10.1007/978-94-017-7197-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC112 _b2015 EB
245	0	0	_aNeuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP) _cedited by Caroline Fonta, László Négyessy
250			_a1st ed. 2015.
264		1	_aDordrecht, Netherlands _bSpringer _c2015
300			_a1 recurso en línea (XXII, 395 p.) _b58 ilustraciones, 37 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aSubcellular Biochemistry _x0306-0225 _v76
505	0		_a1 Clinical forms and animal models of hypophosphatasia -- 2 Molecular genetics of hypophosphatasia and phenotype-genotype correlations -- 3 Genetically modified mice for studying TNAP function -- 4 Tissue-Nonspecific Alkaline Phosphatase in the Developing Brain and in Adult Neurogenesis -- 5 Rediscovering TNAP in the brain: a major role in regulating the function and development of the cerebral cortex -- 6 TNAP in the retina -- 7 Tissue Non-specific Alkaline Phosphatase (TNAP) in vessels of the brain -- 8 What can we learn about the neural functions of TNAP from studies on other organs and tissues? -- 9 TNAP, an essential player in membrane lipid rafts of neuronal cells -- 10 Signal transduction pathways of TNAP: molecular network analyses -- 11 Vitamin B-6 Metabolism and Interactions with TNAP -- 12 Tetramisole and levamisole suppress neuronal activity independently from their inhibitory action on Tissue Non-Specific Alkaline Phosphatase in mouse cortex -- 13 TNAP and Pain Control -- 14 Neurological symptoms of Hypophosphatasia -- 15 Recombinant enzyme replacement therapy in hypophosphatasia -- 16 Neurogenetic Aspects of Hyperphosphatasia in Mabry Syndrome -- 17 The role of tissue non-specific alkaline phosphatase (TNAP) in Neurodegenerative diseases: Alzheimerâ€{u3824}isease in the focus -- 18 TNAP plays a key role in neural differentiation as well as in neurodegenerative disorders -- Index.
520			_aPhosphatases such as TNAP are fundamental in regulating cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. The proposed book aims to provide an overview of our current understanding of the functions of TNAP in the brain.
988			_aEBOOK, EBSPRINGER
650		7	_9676288 _aFosfatasa alcalina _2embne-DP
700	1		_aFonta, Caroline _eeditor literario _994209 _0Local
700	1		_aNégyessy, László _eeditor literario _994210 _0Local
710	2		_aSpringerLink (Online service) _0Local _9106996
830		0	_aSubcellular Biochemistry _x0306-0225 _v76 _9133378
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-94-017-7197-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b11/2020 _dz _eIG _feng _gne _h0