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001			81652
003			ES-MaUEC
005			20230207040340.0
007			cr nn 008mamaa
008			141008s2015 ne | s |||| 0|eng d
020			_a9789400766860
024	7		_a10.1007/978-94-007-6686-0 _2doi
050		4	_aR850.A1 _bI854 2015
082	0	4	_a610
245	1	0	_aIslets of Langerhans _cedited by Md. Shahidul Islam.
250			_a2nd ed. 2015.
260			_aDordrecht, Netherlands _bSpringer _c2015
300			_a1 recurso en línea (170 ilustraciones, 113 ilustraciones en color eReference.
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aMicroscopic Anatomy of the Human Islet of Langerhans -- The Comparative Anatomy of Islets -- Approaches for Imaging Islets: Recent Advances and Future Prospects -- Islet Cell Development -- High Fat Programming of β-Cell Failure -- Electrophysiology of Islet Cells -- ATP-Sensitive Potassium Channels in Health and Disease -- Role of Mitochondria in β-cell Function and Dysfunction -- Basement Membrane in Pancreatic Islet Function -- Calcium Signaling in the Islets -- Electrical Bursting, Calcium Oscillations, and Synchronization of Pancreatic Islets -- Exocytosis in Islet β-Cells -- Proteomics and Islet Research -- Wnt Signaling in Pancreatic Islets -- Mechanisms of Pancreatic β-Cell Apoptosis in Diabetes and Its Therapies -- β-Cell Function in Obese-Hyperglycemic Mice [ob/ob Mice] -- Islet Structure and Function in the GK Rat -- The β-Cell in Human Type 2 Diabetes -- Clinical Approaches to Preserve β-Cell Function in Diabetes -- Immunology of β-Cell Destruction -- Prevention of β-Cell Destruction in Autoimmune Diabetes: Current Approaches and Future Prospects -- Islet Isolation for Clinical Transplantation -- Human Islet Autotransplantation: The Trail Thus Far and the Highway Ahead -- Modulation of Early Inflammatory Reactions to Promote -- Successes and Disappointments with Clinical Islet Transplantation -- Exercise-induced pancreatic islets adaptations in health and disease -- Role Reg family proteins on islet cell growth and survival -- Circadian control of islet function -- Zinc Transporters in the pancreas -- Making Islets from Human Embryonic Stem Cells -- Chloride channels and Transporters in ß-cell physiology -- Pancreatic beta cells in metabolic syndrome -- Insulin and IGF-1 receptor signalling in insulin secreting cells -- Beta cell store-operated ion channels -- Isolation of Rodent Islets of Langerhans -- Anionic TransportersÂ{u086E}d Channels in Pancreatic Islet Cells -- Glucose-Induced Apoptosis in Pancreatics Islets -- In Vivo Biomarkers for Detection of Beta Cell Death -- Inflammatory Pathways Linked to Beta Cell Demise in Diabetes -- Islet Encapsulation -- Islet Isolation for Autotransplantation -- Islet Xenotransplantation: recent advances and future prospects -- Molecular basis of cAMP signaling in pancreatic beta cells -- NADPH Oxidase in Beta Cell Dysfunction -- Pancreatic Neuroendocrine Tumors -- Physiological and Pathophysiological Control of Glucagon Secretion by Pancreatic Alpha-Cells -- Reproductive Hormones and Islet Adaptation to Metabolic Stress -- Stem Cells in Pancreatic Islets -- Transcriptional co-Activators in Beta-Cell Function and Disease Pathology.
520			_aThis book contains critical background information, and recent advances made in essentially all areas of islet research. It is a major reference book, the first of its kind, for islet researchers, and diabetes researchers. Anybody, including the experts, and the beginners, interested in the study of islet physiology, and diabetes, will find this book extremely useful. The book is robust in its breadth: it deals with anatomy, histology, ultra-structure, evolution and comparative anatomy, imaging, developmental biology, programming, apoptosis, mitochondrial function, metabolism, cellular signaling, electrophysiology, oscillation of hormone secretion, islets of model animals, immunology, proteomics, regenerative medicine, clinical advances, and islet transplantation. Individual chapters contributed by a large number of experts and enthusiasts, not only provide a balanced view of the recent advances made in the respective fields, but also provide directions and thoughts for future research. Thanks to vivid and colorful illustrations, tables and sketches, the book as a whole, and the individual chapters make reading a pleasant experience. If you are interested in diabetes research, you will love to have a personal copy of this book.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER
650		7	_aCiencia _2embne _9139568
650		0	_9668476 _aQuímica bioorgánica
650		7	_aDiabetes. _9138582 _2embne
650		7	_aCitología _2embne _9139477
650	2	7	_aCiencias biomédicas _2embne _9143729
650	2	7	_aCitología _2embne _9139477
650	2	7	_aCiencia _2embne _9139568
650	2	4	_9668476 _aQuímica bioorgánica
650		7	_aMedicina _2embne _9405021
650		7	_aFisiología humana _2embne _9140024
650	2	7	_aFisiología humana _2embne _9140024
700	1		_aIslam, Md. Shahidul _eeditor literario _994205 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-94-007-6686-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12902421 _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gne _h0
945			_aR850.A1 I854 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11572048 _z06-04-17
999			_c81652 _d81652 _x1