000			04331nam a22003735i 4500
001			81617
003			ES-MaUEC
005			20230207040338.0
007			cr nn 008mamaa
008			150824s2015 ja | s |||| 0|eng d
020			_a9784431557265
024	7		_a10.1007/978-4-431-55726-5 _2doi
050		4	_aRM301.3.G45 _bI468 2015
245	1	0	_aImmunopharmacogenomics _cedited by Yusuke Nakamura.
250			_a1st ed. 2015.
260			_aTokyo _bSpringer _c2015
300			_a1 recurso en línea (IX, 162 páginas) _b30 ilustraciones, 29 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPART I TECHNOLOGIES -- 1 Deep Sequencing of T-Cell and B-Cell Receptors with Next-Generation DNA Sequencers -- 2 A TCR Sequence Data Analysis Pipeline: Tcrip -- PART II APPLICATIONS -- 3 Prediction of Drug-Induced Adverse Reactions: Skin Hypersensitivity and Liver Toxicity -- 4 Selection and Monitoring of Patients for Immunotherapy (Peptide Vaccines) -- 5 Patient Selection and Monitoring for Immunotherapies: Challenges for Immune Checkpoint Antibody and Cell Therapies -- 6 Better Understanding of Rejection After Organ Transplantation -- 7 Better Understanding of Severe Immunological Reactions: Autoimmune Diseases -- 8 Better Understanding of Severe Immunological Reactions: Food Allergy -- 9 Immune Microenvironment to Predict Response of Cancer Chemotherapy and Radiotherapy -- PART III CHALLENGES AND FUTURE -- 10 Challenges and Future Directions of Immunopharmacogenomics.
520	3		_aThis book proposes immunogenomics, or immunopharmacogenomics, as the next-generation big science to uncover the role that the immune system plays in the pathogenesis of many diseases, by summarizing the importance of the deep sequencing of T-cell and B-cell receptors. Immunogenomics/immunopharmacogenomics, a genetic characterization of the immune system made possible by next-generation sequencing (NGS), will be important for the further understanding of the pathogenesis of various disease conditions. Abnormal immune responses in the body lead to development of autoimmune diseases and food allergies. Rejection of recipient cells and tissues, as well as severe immune reactions to donor cells, is also the result of uncontrolled immune responses in the recipient body. There have been many reports indicating that activated immune responses caused by the interaction of drugs and HLA are present in drug-induced skin hypersensitivity and liver toxicity. The importance of the host immune responses has been recognized in cancer treatments, not only for immunotherapy but also for cytotoxic agents and molecular targeted drugs. Hence, characterization of the T-cell receptor and B-cell receptor repertoire by means of NGS deep sequencing will ultimately make possible the identification of the molecular mechanisms that underlie various diseases and drug responses. In addition, this approach may contribute to the identification of antigens associated with the onset or progression of autoimmune diseases as well as food allergies. Although the germline alterations and somatic mutations have been extensively analyzed, changes or alterations of the immune responses during the course of various disease conditions or during various treatments have not been analyzed. It is also clear that computational analyses to draw meaningful inferences of functional recognition receptors on the immune cells remain a huge challenge.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER, asignarmaterias_11febrero
650		7	_aBiología molecular _2embne _9139103
650		7	_aGenética humana _2embne _9140562
650		7	_aFarmacología _2embne _9137893
700	1		_aNakamura, Yusuke _eeditor literario _994143 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-4-431-55726-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b1290207x _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gja _h0
945			_aRM301.3.G45 I468 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i1157169x _z06-04-17
999			_c81617 _d81617 _x1