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001			81615
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007			cr nn 008mamaa
008			151027s2015 ja | s |||| 0|eng d
020			_a9784431556695
024	7		_a10.1007/978-4-431-55669-5 _2doi
050		4	_aQP751 _b.B563 2015
245	1	0	_aBioactive Lipid Mediators : _bCurrent Reviews and Protocols _cedited by Takehiko Yokomizo, Makoto Murakami.
250			_a1st ed. 2015.
260			_aTokyo _bSpringer _c2015
300			_a1 recurso en línea (IX, 426 páginas) _b95 ilustraciones, 48 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPART I ENZYMES AND RECEPTORS FOR LIPID MEDIATORS -- 1 Lysophospholipid Acyltransferases -- 2 Phospholipase A2 -- 3 Prostaglandin Terminal Synthases as Novel Drug Targets -- 4 Pathophysiological Roles of Prostanoid Receptors in the Central Nervous System -- 5 Lipoxygenases: A Chronological Perspective on the Synthesis of S and R Fatty Acid Hydroperoxides -- 6 Leukotriene B4 Receptors -- 7 Platelet-Activating Factor (PAF) in Infectious Diseases -- 8 Lysophospholipid Mediators: Their Receptors and Synthetic Pathways -- 9 Sphingolipid Metabolism via Sphingosine 1-Phosphate and Its Role in Physiology, Pathology, and Nutrition -- 10 Fatty Acids Receptors -- 11 Omega-3 Fatty Acid Metabolism and Regulation of Inflammation -- PART II LIPID MEDIATORS IN DROSOPHILA AND ZEBRAFISH -- 12 Membrane Lipid Transporters in Drosophila melanogaster -- 13 Drosophila: A Model for Studying Prostaglandin Signaling -- 14 Zebrafish as a Model Animal for Studying Lysophosphatidic Acid Signaling -- 15 Sphingosine 1-Phosphate Signaling via Transporters in Zebrafish and Mice -- PART III LIPID MEDIATORS AND DISEASES -- 16 Lipid Mediator LPA-Induced Demyelination and Self-Amplification of LPA Biosynthesis in Chronic Pain Memory Mechanisms -- 17 Vascular Endothelial S1P2 Receptor Limits Tumor Angiogenesis and Hyperpermeability -- 18 Roles of Prostaglandins in Regulation of Pathological Angiogenesis and Lymphangiogenesis -- 19 Eicosanoids and Aortic Aneurysm -- 20 Cysteinyl Leukotrienes and Disease -- 21 Lipid Mediators and Skin Diseases -- 22 Roles and Actions of Arachidonic Acid-Derived Bioactive Lipids in Stress-Related Behaviors -- PART IV PROTOCOLS FOR ANALYZING LIPID MEDIATORS -- 23 Basic Techniques for Lipid Extraction from Tissues and Cells -- 24 Comprehensive Analysis of Eicosanoids -- 25 Mass Spectrometric Analysis of Phospholipids by Target Discovery Approach -- 26 Determination of Sphingolipids by LC-MS/MS -- 27 Lipid Machinery Investigation Using MALDI Imaging Mass Spectrometry. 28 Measuring Activation of Lipid G Protein-Coupled Receptors Using the TGF-α Shedding Assay -- 29 A Novel Anti-FLAG Monoclonal Antibody is Useful to Study GPCRs -- Index.
520	3		_aThis book summarizes the most recent progress in the studies of lipid mediators from the molecular to clinical level and introduces newly created tools for analysis including imaging mass spectrometry. Comprising 29 chapters divided into four major parts, the book describes the molecular natures of enzymes, transporters, and receptors for lipid mediators (Part I), the function of lipid mediators in Drosophila and Zebrafish (Part II), the relationships between lipid mediators and various diseases (Part III), and detailed procedures of extraction, preparation, and quantification of lipid mediators (Part IV). Research on lipid mediators initially started with analysis of the action of aspirin, and subsequent biochemical experiments identified many enzymes and receptors responsible for the biosynthesis and signal transduction of individual lipid mediators. Through the phenotypic analyses of transgenic and knockout mice, it has been shown that the dysregulation of some lipid mediators causes inflammatory, immune, or oncogenic disorders. Lipid mediators have attracted increased attention because their structures are conserved among different species, and their biosynthetic and signaling pathways have been deciphered at the molecular level. Many drugs that target lipid mediators are already being used in hospitals, and this book suggests further possibilities for development of a wide variety of such drugs. Very recently, highly sensitive mass spectrometry has begun to be used to identify novel lipid mediators that are present only in trace amounts in tissues but with robust biological activity. Written by international experts, this book provides readers a comprehensive view of lipid mediators and related topics and helps in the process of determining research targets for the near future.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER, asignarmaterias_11febrero
650		7	_aLípidos _0 _2embne _9142933
650		7	_aCitología _0 _2embne _9139477
650		7	_aFisiología humana _0 _2embne _9140024
700	1		_aYokomizo, Takehiko _eeditor literario _994138 _0Local
700	1		_aMurakami, Makoto _eeditor literario _994139 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-4-431-55669-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12902056 _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gja _h0
945			_aQP751 .B563 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11571676 _z06-04-17
999			_c81615 _d81615 _x1