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001			81596
003			ES-MaUEC
005			20230207040337.0
007			cr nn 008mamaa
008			150123s2015 ja | s |||| 0|eng d
020			_a9784431551669
024	7		_a10.1007/978-4-431-55166-9 _2doi
050		4	_aQP364.7 _bP747 2015
245	1	0	_aPresynaptic Terminals _cedited by Sumiko Mochida.
260			_aTokyo _bSpringer _c2015
300			_a1 recurso en línea (XIV, 365 páginas) _b35 ilustraciones, 33 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPreface -- Part 1 Overview -- 1 Overview: Presynaptic Terminal Proteins Orchestrate Stepwise Synaptic Vesicle Phases (Sumiko Mochida) -- Part 2 Presynaptic Active Zone Proteins -- 2 Active Zone Assembly (Thomas Dresbach) -- 3 Network of Protein-Protein Interaction at the Presynaptic Active Zone (Toshihisa Ohtsuka) -- Part 3 Synaptic Vesicle Fusion.-Â{u4806}usion Machinery: SNARE Protein Complex (Ira Milosevic and Jakob B. SÃŗensen).-Â{u5812}oles of Tomosyn in Neurotransmitter Release (Yasunori Yamamoto and Toshiaki Sakisaka).-Â{u6812}egulation of SNAREs: Complexin (Hiroshi Tokumaru).-Â{u7814}he Synaptic Vesicle V-ATPase: A Regulatory Link Between Loading and Fusion? (Oussama El Far and Michael Seager).-Â{u8803}a2+ Sensors: Synaptotagmins (Tei-ichi Nishiki, Kentaro Kuroki, Toshio Masumoto, and Hideki Matsui).-Â{u9812}egulation of Active Zone Ca2+ Channels (Karina Leal and Sumiko Mochida) -- Part 4 Synaptic Vesicle Endocytosis -- 10 Endocytic Machinery at the Neuronal Synapse (Ira Milosevic) -- 11 Dynamin is a Key Molecule to Decode Action Potential Firing (Shota Tanifuji and Sumiko Mochida) -- Part 5 Synaptic Vesicle Refilling and Storage -- 12 Transport of Amino Acid Neurotransmitters Into Synaptic Vesicles (Shigeo Takamori) -- 13 Synapsins and Synaptic Vesicle Storage (Fabrizia C. Guarnieri, Fabio Benfenati, and Flavia Valtorta) -- Part 6 Synaptic Vesicle Pools -- 14 Synaptic Vesicle Pools: Classical and Emerging Roles (Sven Truckenbrodt and Silvio O. Rizzoli) -- BM Index.
520	3		_aThis book brings together leading international experts to discuss recent advances in functional studies on key proteins and protein complexes involved in each synaptic vesicle phase. These include proteins that control the final step of neurotransmitter release, in response to a neural signal, and the first step of vesicle endocytosis, which helps maintain stable neurotransmitter release in response to unceasing neural signals arriving at presynaptic terminals. Neural networks transmit input and output signals of action potentials using chemical synapses. The strength of the signal from one to another neuron can be tuned by the neural signal itself as it induces Ca2+ entry and by other neuronsâ€{u0CE9}gnals that modify Ca2+ entry through voltage-gated Ca2+ channels at the active zone, where chemical neurotransmitters are released from synaptic vesicles via exocytosis. Synaptic vesicles are docked and primed at the active zone prior to exocytosis and are endocytosed after exocytosis for reuse at a small presynaptic terminal. Recycled vesicles are refilled with transmitters and stored for a future round of exocytosis. Thus, synaptic vesicles in presynaptic terminals go through various phases. Each vesicle phase is well orchestrated by numerous proteins and advance step-by-step with neural activities. The fine regulations of synaptic vesicle phases by numerous proteins is an exciting subject, and systematic, well-organized explanations in this book will help the reader easily learn about complicated molecular mechanisms in presynaptic terminals.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER, asignarmaterias_11febrero
650		0	_9146728 _aNeuroquímica _0
650		7	_aFisiología humana _0 _2embne _9140024
650		7	_aNeurociencias _0 _2embne _9158907
700	1		_aMochida, Sumiko _eeditor literario _986123 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-4-431-55166-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12901866 _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _gja _h0
945			_aQP364.7 P747 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11571482 _z06-04-17
999			_c81596 _d81596 _x1