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001			81592
003			ES-MaUEC
005			20230207040337.0
007			cr nn 008mamaa
008			151021s2015 ja | s |||| 0|eng d
020			_a9784431545415
024	7		_a10.1007/978-4-431-54541-5 _2doi
050		4	_aRC365 _b.N487 2015 EB
082	0	4	_a612.8
245	1	0	_aNeurodegenerative Disorders as Systemic Diseases _cedited by Keiji Wada
250			_a1st ed. 2015
260			_aTokyo _bSpringer _c2015
300			_a1 recurso en línea (VIII, 304 p.) _b34 ilustraciones, 19 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPART I A NEW CONCEPT OF NEURODEGENERATION IN BIOLOGY AND PATHOPHYSIOLOGY -- 1 Conformational disease and RNA disease theory in the context of neurodegenerative diseases -- 2 Brain-peripheral organ communication -- 3 The brain-immune network in spinal cord injury -- PART II CHANGES IN CLINICAL EVALUATION AND NEW BIOMARKERS -- 4 Renovation of clinical evaluation and new biomarkers -- 5 Clinical Systems Neuroscience -- PART III RISK FACTORS IN NEURODEGENERATION -- 6 Genetic risk factors for neurodegenerative diseases -- 7 Intermediate phenotypes approach for neuropsychiatric disorders -- PART IV FUTURE DIRECTIONS FOR THERAPY -- 8 Significance of mechanism-oriented research toward neuronal protection therapy against neurodegenerative disorders ~ ZNRF1 E3 ubiquitin ligase as a critical mediator for Wallerian degeneration and neuronal apoptosis -- 9 Drug development for neurodegenerative diseases -- 10 Physical therapy and rehabilitation in patients with degenerative cerebellar diseases: current evidence and future direction -- 11 Home- and Community-based medical care for neurodegenerative diseases -ALS as an illustration- -- PART V HEALTH PROMOTION: PREVENTION AND QUALITY OF LIFE -- 12 Information Environment and Brain Function: A New Concept of the Environment for the Brain -- 13 Social Implementation of Neurodegenerative Disease Research and Neuroethics.-.
520	3		_aThis book sheds new light on neurodegenerative disorders as systemic diseases. Classically, neuronal cell death was a hallmark of such disorders. However, it has become evident that neural dysfunction is more important in the pathophysiology of neurodegenerative disorders. More recently, the prionoid-spreading hypothesis of disease-causing molecules has attracted a great deal of attention. Therapeutic strategies thus must be reconsidered in the light that neurodegenerative disorders are indeed systemic diseases. The first part of this book introduces the concept of neurodegeneration in biology and pathophysiology. The second part focuses on clinical evaluation and biomarkers from the perspective of this new concept, while the third summarizes the risk factors of neurodegeneration. The fourth part of this work indicates future directions of treatment, and the final part discusses health promotion for prevention and quality of life. This book will be of interest to both researchers and medical personnel, and provides a fresh approach to neurodegenerative diseases, paving the way to new research and improved quality of health care for patients
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER
650		7	_aSistema nervioso _xDegeneración _9313064 _0comprobar BNE20012072191 _2embne
650		7	_aNeurociencias _0comprobar BNE20012490612 _2embne _9158907
700	1		_aWada, Keiji _eeditor literario _994087 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-4-431-54541-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9784431545415
907			_a.b12901829 _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b19-06-17 _cm _dz _ek _feng _gja _h0
945			_aRC365 .N487 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11571445 _z06-04-17
999			_c81592 _d81592 _x1