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001			81569
003			ES-MaUEC
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007			cr nn 008mamaa
008			150406s2015 gw | s |||| 0|eng d
020			_a9783662464502
024	7		_a10.1007/978-3-662-46450-2 _2doi
050		4	_aRB127 _b.P356 2015
245	1	0	_aPain Control _cedited by Hans-Georg Schaible.
260			_aBerlin, Heidelberg _bSpringer _c2015
300			_a1 recurso en línea (VIII, 309 páginas) _b31 ilustraciones, 22 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aHandbook of Experimental Pharmacology _x0171-2004 _v227
505	0		_aEmerging concepts of pain therapy based on neuronal mechanisms -- The pharmacology of nociceptor priming -- Sodium channels and pain -- Role of nerve growth factor in pain -- Central sensitization in humans â€{u0873}sessment and pharmacology -- The role of NO in the spinal cord -- The role of the endocannabinoid system in pain -- The role of glia in the spinal cord in neuropathic and inflammatory pain -- Plasticity of inhibition in the spinal cord -- Gene regulation in nociception. Modulation of peripheral inflammation by the spinal cord -- The relationship between opioids and cytokines in the spinal cord -- The role of proteases in pain.Â{u0869}n-related pharmacology in the amygdala -- Pain and itch â€{u0929}fferences and commonalities.
520	3		_aThis volume addresses neuronal pain mechanisms at the peripheral, spinal and supraspinal level which are thought to significantly contribute to pain and which may be the basis for the development of new treatment principles. Chapters on nociceptive mechanisms in the peripheral nociceptive system address the concept of hyperalgesic priming, the role of voltage-gated sodium channels in different inflammatory and neuropathic pain states, the hyperalgesic effects of NGF in different tissues and in inflammatory and neuropathic pain states, and the contribution of proteinase activated receptors (PAR) to the development of pain in several chronic pain conditions. Chapters on nociceptive mechanisms in the spinal cord address the particular role of NO and of glial cell activation in the generation and maintenance of inflammatory and neuropathic pain and it discusses the potential role of local inhibitory interneurons, of the endogenous endocannabinoid system and the importance of non-neuronal immune mechanisms in opioid signaling in the control of pain. Furthermore, it is presented how spinal mechanisms contribute to the expression of peripheral inflammation.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER, asignarmaterias_11febrero
650		7	_aBioquímica clínica _0 _2embne _9149316
650		7	_aFisiología humana _0 _2embne _9140024
650		7	_aFarmacología _0 _2embne _9137893
700	1		_aSchaible, Hans-Georg _eeditor literario _994055 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-662-46450-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12901593 _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aRB127 .P356 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11571214 _z06-04-17
999			_c81569 _d81569 _x1