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007			cr nn 008mamaa
008			150410s2015 gw | s |||| 0|eng d
020			_a9783662446058
024	7		_a10.1007/978-3-662-44605-8 _2doi
050		4	_aRL721 _b.P437 2015
245	1	0	_aPharmacology of Itch _cedited by Alan Cowan, Gil Yosipovitch.
260			_aBerlin, Heidelberg _bSpringer _c2015
300			_a1 recurso en línea (VIII, 382 páginas) _b42 ilustraciones, 34 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aHandbook of Experimental Pharmacology _x0171-2004 _v226
505	0		_aHistorical Background -- Epidemiology of the Burden of Chronic Itch -- Neurophysiology and Itch Pathways -- Brain Mechanisms of Chronic Itch -- Mouse and Human Models of Itch. Transient Receptor Potential Channels and Itch -- Cytokines and Itch -- Role of Mrgpr Family of Receptors and Itch -- Protease-activated Receptor Agonists and Itch -- VGLUT2-dependent Sensory Neurons and Itch -- Identification and Characterization of Spinal Inhibitory Neurons That Inhibit Itch -- Noradrenergic Itch Transmission in the Spinal Cord -- NK-1 Antagonists and Itch -- Cannabinoids and Itch -- Antihistamines and Itch -- Targeting Itch with Ligands Selective for k Opioid Receptors -- Neuraxial Opioid-induced Scratching and Its Pharmacological Antagonism -- Topical Therapies -- Allergic Itch in Dogs.
520	3		_aBasic research on the pharmacology of itch has explodedÂ{u9BA0}the wakeÂ{uF9A0}two very influential papers that were published in Nature (2007) and Science (2009). Long overlooked as a milder form of pain, itching has rapidly gained a new appreciation in both research and clinical communities because of its complexity and its negative effects on the quality of life of the distressed patients. Like pain, not all itches are the same. Unlike pain, there are no standard drugs equivalent to aspirin and morphine. Epidemiological studies emphasize the high incidence and economic costs of itch (pruritus). It is the most prevalent symptom of a wide variety of allergic and inflammatory skin conditions (e.g., psoriasis, atopic dermatitis), is associated with several systemic diseases (e.g., chronic kidney and liver disease), and occurs in patients undergoing hemodialysis, spinal administration of opioids, and in those suffering from AIDS. The reader will learn about the multiple pathways for itch and their interactions with pain. The relationship between these closely related, yet distinct sensory phenomena, will be emphasized. Both itch and pain use several common molecules to send signals to the brain. Thus, drugs that have been, and are being, developed as analgesics may also attenuate intractable itch. This has been an exciting and very necessary turn of events since traditional H-1 receptor antagonists are ineffective in blocking the pruritus associated with kidney failure and cholestasis. The clinical chapters will provide insights into contemporary treatment regimens for pruritus in different human scenarios.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER, asignarmaterias_11febrero
650		7	_aAlergia _2embne _9138329
650		7	_aInmunología _2embne _9138330
650		7	_aFarmacología _2embne _9137893
700	1		_aCowan, Alan _eeditor literario _994034 _0Local
700	1		_aYosipovitch, Gil _eeditor literario _993172 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-662-44605-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12901453 _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aRL721 .P437 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i1157107x _z06-04-17
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