000			02753nam a22003375i 4500
001			81535
003			ES-MaUEC
005			20230202102953.0
007			cr nn 008mamaa
008			151126s2015 gw | s |||| 0|eng d
020			_a9783319246635
040			_aES-MaUEC
050		4	_aQR181 _b.R533 2015 EB
100	1		_aRibatti, Domenico _986304 _0Local
245	1	4	_aThe Development of Immunologic Competence _cby Domenico Ribatti
250			_a1st ed. 2015
260			_aCham, Switzerland _bSpringer _c2015
300			_a1 recurso en línea (VIII, 60 p.) _b29 il., 7 il. col.
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
520			_aThis book traces significant aspects of the history of immunology, exploring the immune system and immunodeficiency. The author recounts human hematopoietic development, and how a distinction of the immune system into thymus-dependent and thymus-independent components has been demonstrated in different animal species, including amphibians, birds, and mammals. Other themes explored in this book include discoveries about the role of the thymus of the Bursa of Fabricius in the development of immunologic competence, and observations on the changes in the lymphoid organs after bursectomy and thymectomy in chickens. Readers will discover how the bursa provides a unique microenvironment for the proliferation and differentiation of B cells, while thymectomized and irradiated animals were deficient in lymphocytes that mediated inflammatory responses, as assessed by skin graft rejection, delayed-type hypersensitivity, and graft versus host reaction. A clear perspective for understanding several diseases and also the entire lymphoid system emerges through the experiments and extensive histopathological studies of patients with primary immunodeficiency diseases that are described in these chapters. Researchers in the life sciences, in biomedicine and the history of medicine will all find something of value in this highly engaging work. It will also appeal to those with an interest in public health and neurobiology.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER
650		7	_aInmunología _0comprobar BNE19900958507 _2embne _9138330
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-24663-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319246635
907			_a.b12901258 _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b22-03-17 _cm _dz _eo _feng _ggw _h4
945			_aQR181 .R533 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11570878 _z06-04-17
999			_c81535 _d81535 _x1