000			04764nam a22003855i 4500
001			81526
003			ES-MaUEC
005			20230207040334.0
007			cr nn 008mamaa
008			151130s2015 gw | s |||| 0|eng d
020			_a9783319236032
024	7		_a10.1007/978-3-319-23603-2 _2doi
050		4	_aQH301 _b.P765 2015
245	1	0	_aProkaryotic Systems Biology _cedited by Nevan J. Krogan, PhD, Mohan Babu, PhD.
260			_aCham, Switzerland _bSpringer _c2015
300			_a1 recurso en línea (IX, 319 páginas) _b58 ilustraciones, 55 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v883
505	0		_aMetagenomics as a Tool for Enzyme Discovery: Hydrolytic Enzymes from Marine-related Metagenomes -- Investigating Bacterial Protein Synthesis Using Systems Biology Approaches -- Biology and Assembly of the Bacterial Envelope -- Comparative Genomics and Evolutionary Modularity of Prokaryotes -- Predicting Functional Interactions among Genes in Prokaryotes by Genomic Context -- Functional Implications for Domain Organization within Prokaryotic Rhomboid Proteases -- Mapping Transcription Regulatory Networks with ChIP-seq and RNA-seq -- Quantitative and Systems-Based Approaches for Deciphering Bacterial Membrane Interactome and Gene Function -- Toward Network Biology in E. coli Cell -- Genetic Interaction Scoring Procedure for Bacterial Species -- Mapping the Proteinâ€{u0CAF}tein Interactome Networks Using Yeast Two-Hybrid Screens -- Biogenesis of Escherichia coli DMSO Reductase: A Network of Participants for Protein Folding and Complex Enzyme Maturation -- Microbial Proteome Profiling and Systems Biology: Applications to Mycobacterium tuberculosis -- Structural Aspects of Bacterial Outer Membrane Protein Assembly -- Substrate Interaction Networks of the Escherichia coli Chaperones: Trigger Factor, DnaK and GroEL -- Genetic, Biochemical, and Structural Analyses of Bacterial Surface Polysaccharides.
520	3		_aThis book focuses on innovative experimental and computational approaches for charting interaction networks in bacterial species. The first part of the volume consists of nine chapters, focusing on biochemical and genetics and genomics approaches including yeast two hybrid, metagenomics, affinity purification in combination with mass spectrometry, chromatin-immunoprecipitation coupled with sequencing, large-scale synthetic genetic screens, and quantitative-based mass spectrometry strategies for mapping the bacterial physical, functional, substrate, and regulatory interaction networks needed for interpreting biological networks, inferring gene function, enzyme discovery, and identifying new drug targets. The second part comprises five chapters, covering the network of participants for protein folding and complex enzyme maturation. It also covers the structural approaches required to understand bacterial intramembrane proteolysis and the structure and function of bacterial proteins involved in surface polysaccharides, outer membrane, and envelope assembly. This volume concludes with a focus on computational and comparative genomics approaches, especially network-based methods for predicting physical or functional interactions, and integrative analytical approaches for generating more reliable information on bacterial gene function. This book provides foundational knowledge in the understanding of prokaryotic systems biology by illuminating how bacterial genes f unction within the framework of global cellular processes. The book will enable the microbiology community to create substantive resources for addressing many pending unanswered questions, and facilitate the development of new technologies that can be applied to other bacterial species lacking experimental data.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER, asignarmaterias_11febrero
650		0	_9430647 _aProteómica _0
650		7	_aSistemas biológicos _0 _2embne _9403517
650		0	_9138907 _aBacteriología _0
700	1		_aKrogan, PhD, Nevan J. _eeditor literario _0Local _993990
700	1		_aBabu, Mohan _eeditor literario _0Local _993991
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-23603-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12901167 _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aQH301 .P765 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11570787 _z06-04-17
999			_c81526 _d81526 _x1