000			02688nam a22003375i 4500
001			81505
003			ES-MaUEC
005			20230202102945.0
007			cr nn 008mamaa
008			151130s2015 gw | s |||| 0|eng d
020			_a9783319224732
040			_aES-MaUEC
050		4	_aQP551 _b.P768 2015 EB
245	0	0	_aProtein Targeting Compounds : _bPrediction, Selection and Activity of Specific Inhibitors _cedited by Thomas Böldicke
250			_a1st ed. 2015
260			_aCham, Switzerland _bSpringer _c2015
300			_a1 recurso en línea (VIII, 288 p.) _b49 il., 31 il. col.
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
520			_aThis book presents an overview of the most relevant protein knockdown techniques. Readers will find a description of the generation and use of recombinant human antibodies, ER intrabodies and peptides as well as a description of the working mechanism and potential of the inhibitory action of each of these molecules. The book will also describe the selection and activity of a number of phosphatases, aptamers and allosteric modulators, focusing on A G protein coupled receptors. The book starts with a chapter on the in silico prediction of target-inhibitor interactions. Key aspects of this book are: - Selection strategies for monoclonal and recombinant human antibodies - Selection strategies for ER intrabodies, peptides and aptamers - Examples of the most efficient inhibitors and their applications in protein biochemistry and cell biology - Antibodies for cancer therapy and inhibitors of angiogenesis. The book will be of great interest to scientists and students working in the life sciences on all areas related to protein biology. The variety of methods to modulate the activities of specific proteins which are introduced here will be of great benefit to the reader who is interested in general protein research or to readers who have very specific protein related questions.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER
650		7	_aProteínas _0comprobar BNE19900977845 _2embne _9139861
700	1		_aBöldicke, Thomas _eeditor literario _993968 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-22473-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9783319224732
907			_a.b12900953 _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b22-03-17 _cm _dz _eo _feng _ggw _h0
945			_aQP551 .P768 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i1157057x _z06-04-17
999			_c81505 _d81505 _x1