000			04034nam a22003855i 4500
001			81500
003			ES-MaUEC
005			20230207040332.0
007			cr nn 008mamaa
008			151106s2015 gw | s |||| 0|eng d
020			_a9783319221175
024	7		_a10.1007/978-3-319-22117-5 _2doi
050		4	_aRC632.P7 _bB435 2015
100	1		_aBeckerman, Martin _0Local _993961
245	1	0	_aFundamentals of Neurodegeneration and Protein Misfolding Disorders _cby Martin Beckerman.
250			_a1st ed. 2015.
260			_aCham, Switzerland _bSpringer _c2015
300			_a1 recurso en línea (XXII, 378 páginas) _b122 ilustraciones, 103 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aBiological and Medical Physics, Biomedical Engineering _x1618-7210
505	0		_aIntroduction -- Protein Folding, Part I: Basic Principles -- Protein Folding, Part II: Energy Landscapes and Protein Dynamics -- Protein Misfolding and Aggregation -- Protein Quality Control, Part I: Molecular Chaperones and the Ubiquitin-Proteasome System -- Protein Quality Control, Part II: Autophagy and Aging -- Prion Diseases -- Alzheimerâ€{u3804}isease -- Parkinsonâ€{u3804}isease -- Huntingtonâ€{u3804}isease and other Unstable Repeat Disorders -- Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration.
520	3		_aThis unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts.Â{u4A25}se findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimerâ€{u3824}isease and Parkinsonâ€{u3824}isease to Huntingtonâ€{u3824}isease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative butÂ{u7CA9}tten in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding DisordersÂ{u1924}resses one of todayâ€{u3826}orefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER, asignarmaterias_11febrero
650		7	_aAnálisis clínicos _2embne _9138438
650		7	_aProteínas _2embne _9139861
650		7	_aNeurociencias _2embne _9158907
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-22117-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12900904 _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aRC632.P7 B435 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11570520 _z06-04-17
999			_c81500 _d81500 _x1