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001			81488
003			ES-MaUEC
005			20230207040332.0
007			cr nn 008mamaa
008			150801s2015 gw | s |||| 0|eng d
020			_a9783319211008
024	7		_a10.1007/978-3-319-21100-8 _2doi
050		4	_aRC280.T5 _bH863 2015
245	1	0	_aHuman Papillomavirus (HPV)-Associated Oropharyngeal Cancer _cedited by Daniel L. Miller, M. Sharon Stack.
250			_a1st ed. 2015.
260			_aCham, Switzerland _bSpringer _c2015
300			_a1 recurso en línea (VIII, 314 páginas) _b29 ilustraciones, 22 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aEpidemiology of HPV-Associated Oropharyngeal Squamous Cell Carcinoma -- Behavioral Correlates of HPV-Associated Oropharyngeal Squamous Cell Carcinomas -- Racial Disparities in Oropharyngeal Cancer -- HPV Virology: Cellular Targets of HPV Oncogenes and Transformation -- Papillomavirus Replication -- MicroRNA Profiles of HPV-AssociatedÂ{u03F2}opharyngeal Squamous Cell Carcinoma (OPSCC) -- Targeting the PI3K-mTOR Signaling Circuitry in HPV-Associated Oral Malignancies: Novel Precision Molecular Therapies -- Mutational Profile of HPV-Positive HNSCC -- Clinical Presentation of HPV-driven Oropharyngeal Carcinoma -- Differences and Similarities between HPV-Associated OPSCC and Cervical Cancer -- Surgical Perspective in the Management of Oropharyngeal Cancer -- HPV and Radiation Sensitivity -- The Role of Immune Modulation in the Carcinogenesis and Treatment of HPV-associated Oropharyngeal Cancer.
520	3		_aHead and neck squamous cell carcinoma (HNSCC), the sixth most prevalent cancer worldwide, remains a very difficult disease to treat and cure despite intensive investigation into molecular etiologies and tumor progression pathways. Due to public health efforts encouraging smoking cessation, the overall incidence of HNSCC has decreased in recent years in many countries. Â{u9BA0} contrast, the incidence of oropharyngeal squamous cell carcinoma (OPSCC) has increased significantly, and this subtype of HNSCC is commonly associated with human papillomavirus (HPV) infection.Â{u036F}reover, individuals with HPV-positive OPSCC are generally younger and are frequently non-smokers, suggesting that HPV-associated OPSCC represents a distinct biologic entity. This volume summarizes the spectrum of current HPV-associated OPSCC research from the fundamental basic science to translational surgery and treatment approaches. Chapters are contributed by authoritative leaders in the fields of research and clinical care. Initial chapters address epidemiology, behavioral correlates of HPV infection, and racial disparities in oropharyngeal cancer. This is followed by chapters detailing HPV virology with focus on viral transformation, viral replication, and host response to viral infection. The molecular biology of HPV-associated OPSCC is investigated in chapters detailing alterations in signaling networks and unique mutational profiles of human tumors. Clinical presentation, surgical perspectives, and treatment paradigms specific to HPV-associated OPSCC conclude the volume.This comprehensive volume provides an up-to-date overview of both scientific discovery and clinical management of this emerging public health problem.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER, asignarmaterias_11febrero
650		0	_9405049 _aMicrobiología médica
650		7	_aVirología _2embne _9413113
650		7	_aInmunología _2embne _9138330
700	1		_aMiller, Daniel L _eeditor literario _993948 _0Local
700	1		_aStack, M. Sharon _eeditor literario _993949 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-21100-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12900783 _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aRC280.T5 H863 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11570404 _z06-04-17
999			_c81488 _d81488 _x1