000			03290nam a22003615i 4500
001			81459
003			ES-MaUEC
005			20230207040331.0
007			cr nn 008mamaa
008			150717s2015 gw | s |||| 0|eng d
020			_a9783319200989
024	7		_a10.1007/978-3-319-20098-9 _2doi
050		4	_aQP606.P78 _bS536 2015
245	1	0	_aSH Domains : _bStructure, Mechanisms and Applications _cedited by Natalya Kurochkina.
260			_aCham, Switzerland _bSpringer _c2015
300			_a1 recurso en línea (VIII, 253 páginas) _b52 ilustraciones, 30 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aSH3 Domains as Suitable Models to Study Amyloid Aggregation -- SH Domain Proteins in Plants: Roles in Signaling Transduction and Membrane Trafficking -- Versatility of SH3 Domains in the Cellular Machinery -- Structure-Function Relationship of Bacterial SH3 Domains -- Activation of PI3K by Thyroid Hormone Nuclear Receptors -- SH Domainsâ€{u026E}teraction with SliMs: Maximizing Adaptivity of Signaling Networks -- SH Domains and Epidermal Growth Factor Receptor -- SH2 Domain Structures and Interactions -- Cytoskeletal Signaling by Src Homology Domain-Containing Adaptor Proteins -- Structure and Function of Jak3- SH2 Domain -- Helical Assemblies and SH Domains.
520	3		_aThis book covers structure, function, and important roles of the SH domains, structure-function relationships, the versatile nature of their action, mechanisms of aggregation, specificity of interactions, impact of mutations on protein functional dysregulation, and cell signaling. Their involvement in various cellular processes such as migration, invasiveness, actin reorganization, shaping spines, determination of the morphology assembly of fibrils, and mechanotransduction makes these molecules attractive drug targets. Substrates, inhibitors and activators of PTKsÂ{u0CA5}sent a wide variety of therapeutic agents in the context of delivering treatments for numerous pathologies. The new emerging field of stem cell therapies and design of biomaterials for treatments relies on the directed regulation of stem cell growth, differentiation and morphology, as well as the production of biomimetic scaffolds that respond to programmed signals. Advances in deciphering the mechanisms of action of these important molecules will lead to the implementation and success of their vital applications.
710	2		_aSpringerLink (Online service) _0Local _9106996
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGER, asignarmaterias_11febrero
650		7	_aProteínas _0 _2embne _9139861
650		7	_aCitología _0 _2embne _9139477
650	2	7	_aProteínas _0 _2embne _9139861
700	1		_aKurochkina, Natalya _eeditor literario _993900 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-319-20098-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12900497 _b10-10-17 _c18-01-16
998			_am _a_alco _a_vill _b - - _cm _dz _e- _feng _ggw _h0
945			_aQP606.P78 S536 2015 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11570118 _z06-04-17
999			_c81459 _d81459 _x1